NATURALLY OCCURRING STEROIDS CONTAINING A TERTIARY BUTYL GROUP AND THEIR BIOLOGICAL ACTIVITIES
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 11
Abstract
The present review article describes distribution and biological activities of steroids containing a tertiary butyl group. More than 65 biological active steroids have shown confirmed antitumor, antiviral, or apoptosis, and other activities. The structures, reported and predicted activities of a selection of describes steroids are reported. With the computer program PASS based on structure–activity relationships (SAR) some additional activities are also predicted, which point toward new possible applications of these lipids. This article emphasizes the role of steroids containing a tertiary butyl group as an important source of leads for drug discovery.
Authors and Affiliations
Dr. Valery M. Dembitsky
Keywords
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- EP ID EP630369
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