Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 2
Abstract
Traditional herbal healers “Hakims” use various plants of the Cholistan desert, Pakistan for treating a number of infectious and non-infectious diseases. However, there has never been a scientific validation of these plant-based therapeutics. We compared the antipyretic effect of Echinops echinatus, Alhagi maurorum, Fagonia cretica, Cymbopogon jwarancusa and Panicum turgidum in animal model. These plants were used to reduce E.coli lysate induced pyrexia in rabbits. There were five groups of rabbits having five rabbits in each group. Among these five groups, three received various doses of experimental treatment, paracetamol was given to fourth group known as positive control. The fifth group of animals served as negative control and received no treatment. Ethanol extracts of Fagonia cretica (500mg/kg), Panicum turgidum (500mg/kg and 750mg/kg), Alhagi maurorum (500 and 750mg/kg), Cymbopogon jwarancusa (250mg/kg) and Echinops echinatus (750mg/kg) showed significant antipyretic effects when compared with controls and experimental counterparts. These results revealed that ethanol extracts of the plants evaluated in this study have dose dependent antipyretic activity. Further detailed screening of these plant species is recommended.
Authors and Affiliations
Muhammad Khurshid Alam , Saeed Ahmed , Shazia Anjum , Muhammad Akram , Syed Muhammad Ali Shah , Hafiz Muhammad Wariss , Muhammad Mohtasheemul Hasan
Effect of fasting on serum lithium levels: An experimental Study in animal models
Muslims throughout the world observe dawn to dusk fast in the month of Holy Ramadan. This study aims to investigate the effect of fasting on serum lithium levels in an animal model under typical conditions of Ramad...
Pharmacokinetics of fexofenadine in healthy Taiwanese volunteers
The aim of presented study was to assess pharmacokinetic properties of fexofenadine in Taiwanese volunteers. Thirty-three healthy male subjects received 180mg fexofenadine. Blood samples were drawn at appropriate t...
Inhibitory effects of Olea ferruginea crude leaves extract against some bacterial and fungal pathogen
This work aimed to evaluate the inhibitory effects of Olea ferruginea crude leaves extract that are commonly used as remedy to cure infections in the tribal (Khyber Agency) areas of Pakistan against some of bacterial and...
Hijama improves overall quality of life in chronic renal failure patients: A pilot study
Present study assesses the therapeutic effectiveness of Hijama (blood letting) inpatients of chronic renal failure undergoing hemodialysis for past several years with almost no urinary output.24 patients from Sindh...
The effect of hydro alcoholic extract of Juglans regia leaves in streptozotocin-nicotinamide induced diabetic rats
Phytotherapy has been achieved to maintain glycemic control in patients with diabetes mellitus. The present study was conducted to evaluate the antihyperglycemic properties of the Juglans regia leaf extract in streptozot...