ALBUMINURIA AND DIABETES MELLITUS TYPE 2: AN OBSERVATIONAL STUDY FROM BARABANKI, LUCKNOW
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2015, Vol 4, Issue 35
Abstract
[b] INTRODUCTION[/b]: India leads the world with largest number of diabetic subjects and this is expected to further rise in coming years. Diabetic nephropathy affects 20-30% of patients with diabetes. It presents in its earliest stage with low levels of albumin in the urine (micro-albuminuria). The determination of micro-albuminuria in diabetes mellitus is important as it is the earliest indication of diabetic nephropathy. When left untreated, it will eventually lead to end stage renal disease (ESRD). [b]OBJECTIVE[/b]: To detect the onset of albuminuria among diabetic patients and the effect of hyperglycemia in causing this condition at an early stage. [b]MATERIALS AND METHODS[/b]: One hundred clinically diagnosed cases of non-insulin dependent diabetes mellitus (NIDDM) were selected for the study, from Feb-2014 to May-2014 (4 months). Criteria for the diagnosis of DM were of patients having fasting blood glucose levels more than 126 mg/dl. Micro-albuminuria is defined when urinary albumin excretion rate (UAER) in 24-hr urine or short time collected urine during the day time is in the range of 30-300 mg/24-hrs. If excretion is less than 20 µgm/min, the patient is considered to have normo-albuminuria, and if excretion is higher than 200 µgm/min, he is considered to have macro-albuminuria or clinical proteinuria. The data for biochemical analysis are expressed as means±S.E.M. [b]OBSERVATION[/b]: In our study 35% of the total patients developed albuminuria, while 65% were free from it. 10% patients developed micro-albuminuria who was less than 50 yrs, while it was seen in 15% patients having age more than 50 yrs. Our study shows that only 5% patients developed macro-albuminuria. Glycosylated haemoglobin and fasting plasma glucose was significantly raised among all these patients. [b]Conclusion[/b]: Considering the tremendous increase in the number of diabetic patients in India and health budgets of our country, an early detection and good control of diabetes to reduce the burden of diabetic kidney disease is necessary.
Authors and Affiliations
Vivek Sinha, Kashif Shahnawaz
Keywords
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- EP ID EP143414
- DOI 10.14260/jemds/2015/876
- Views 70
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