COMPARATIVE STUDY OF TOURNIQUET V/S TRANEXAMIC ACID USE ON BLOOD LOSS IN TOTAL KNEE ARTHROPLASTY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2015, Vol 4, Issue 48
Abstract
[b]CONTEXT[/b]: Total knee replacement (TKR) is often carried out using a tourniquet to minimize intraoperative blood loss. However, its application enhances local fibrinolysis, resulting in excessive blood loss during the post-operative period. Fibrinolytic profile varies in different regions and races. Tranexamic acid has been shown to reduce post-operative blood loss and the need for transfusion in TKR. However, there is paucity of literature from the Indian population and the efficacy of the agent has not been tested in Indian patients undergoing TKR. [b]AIMS[/b]: Effect of tranexamic acid without use of tourniquet V/S tourniquet use on blood loss in TKR surgery in the Indian population. [b]SETTING AND DESIGN[/b]: In this study, 40 patients undergoing unilateral TKR were randomly divided into two groups. [b]METHODS[/b]: All patients were conducted under spinal anaesthesia using injection bupivacaine 0.5% heavy 12-15 mg. One group received 10 mg/kg tranexamic acid, intravenous (IV), half an hour before deflation of the tourniquet without use of tourniquet, with a second dose of 2 mg/kg administered 3 hours after the first dose. Other group underwent TKR under tourniquet which was inflated before surgery and deflated after compression.
Authors and Affiliations
Baljit Singh, Shaleen Sareen, Gurminder Singh, Aditya Bharadwaj, Chander Singh
Keywords
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- EP ID EP90268
- DOI 10.14260/jemds/2015/1209
- Views 101
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