STUDY OF LIPID PEROXIDATION, ANTIOXIDANT STATUS, LIPID PROFILE AND HOMOCYSTEINE LEVELS IN BREAST CANCER

Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2015, Vol 4, Issue 32

Abstract

 [b] OBJECTIVE[/b]: Breast cancer is the commonest malignancy in women in India and western countries. Increased production of oxygen free radicals exhaust the antioxidant levels in the body leading to the development of oxidative stress which results in the production of cancer. The reason for alteration of lipid profile and homocysteine levels in breast cancer is not clearly understood. The aim of our present study is to evaluate the role of oxidative stress and also the status of serum lipid profile and homocysteine levels in breast cancer patients. [b]METHODS[/b]: The role of oxidative stress in breast cancer patients were evaluated by estimating the levels of lipid peroxidation assessing plasma Malondialdehyde (MDA) levels and antioxidant status by reduced glutathione (GSH) , Vitamin-C in blood. We also tried to assess lipid profile by estimating Serum total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol and we also assessed total homocysteine levels. For this, we have taken 50 cases of breast cancer patients compared with 50 age matched control women.[b] RESULTS[/b]: There were significant increase in the levels of MDA and significant decreases in the levels of antioxidants like GSH and Vitamin-C in breast cancer patients when compared with controls. There were also significant increase in the levels of Serum total cholesterol, triglycerides and LDL cholesterol and no statistical significant difference was observed with HDL cholesterol in cases when compared with controls. There was significant increase in the levels of homocysteine levels in cases when compared with controls. [b]CONCLUSION[/b]: Our results indicate that oxidative stress and alterations in lipid profile and homocysteine levels are associated with the development of breast cancer and the need for modification of lifestyle for the reduction of breast cancer development.

Authors and Affiliations

Hareesh G. S. R, Neelima Parlapalli, Kedari G. S. R

Keywords

Related Articles

URINARY TRACT INFECTION IN PREGNANCY

BACKGROUND Urinary tract infection in pregnancy is one of the most common bacterial infections, which if not treated can cause serious harm to both mother and foetus. A woman is predisposed to urinary tract infection bec...

STUDY OF SERUM TOTAL THIOL LEVELS AND LIPID PEROXIDATION AS INDICATOR OF OXIDATIVE STRESS IN PATIENTS OF ACUTE CENTRAL SEROUS RETINOPATHY

BACKGROUND ''Central Serous Retinopathy (CSCR) is an idiopathic, commonly encountered retinal disease, in which stress has been implicated to play a possible role. Our study aimed to determine the role of oxidative stres...

STUDY OF CLINICAL PROFILE AND RISK FACTORS OF PNEUMONIA (CAP)

BACKGROUND Community-acquired pneumonia (CAP), the most common type of pneumonia is one of the commonest infectious diseases and is an important cause of mortality and morbidity in all age groups worldwide. Identifying p...

SALIVARY GLAND ONCOCYTOMA AND EVOLUTION OF ONCOCYTES

BACKGROUND Various glandular and secretory epithelia show oncocytes. Most of the oncocytic lesions are benign with a relatively low rate of proliferation. Oncocytomas form less than 1% of all benign salivary gland tumour...

EVALUATION OF MASS DRUG ADMINISTRATION FOR FILARIASIS IN BOUDH DISTRICT, ODISHA

BACKGROUND Lymphatic Filariasis (LF) is one of the oldest and most debilitating neglected tropical diseases, recognised by World Health Organisation (WHO) as a group of parasitic infections which primarily affect people...

Download PDF file
  • EP ID EP153772
  • DOI 10.14260/jemds/2015/813
  • Views 85
  • Downloads 0

How To Cite

Hareesh G. S. R, Neelima Parlapalli, Kedari G. S. R (2015).   STUDY OF LIPID PEROXIDATION, ANTIOXIDANT STATUS, LIPID PROFILE AND HOMOCYSTEINE LEVELS IN BREAST CANCER. Journal of Evolution of Medical and Dental Sciences, 4(32), 5563-5568. https://europub.co.uk/articles/-A-153772