STUDY OF LIPID PEROXIDATION, ANTIOXIDANT STATUS, LIPID PROFILE AND HOMOCYSTEINE LEVELS IN BREAST CANCER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2015, Vol 4, Issue 32
Abstract
[b] OBJECTIVE[/b]: Breast cancer is the commonest malignancy in women in India and western countries. Increased production of oxygen free radicals exhaust the antioxidant levels in the body leading to the development of oxidative stress which results in the production of cancer. The reason for alteration of lipid profile and homocysteine levels in breast cancer is not clearly understood. The aim of our present study is to evaluate the role of oxidative stress and also the status of serum lipid profile and homocysteine levels in breast cancer patients. [b]METHODS[/b]: The role of oxidative stress in breast cancer patients were evaluated by estimating the levels of lipid peroxidation assessing plasma Malondialdehyde (MDA) levels and antioxidant status by reduced glutathione (GSH) , Vitamin-C in blood. We also tried to assess lipid profile by estimating Serum total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol and we also assessed total homocysteine levels. For this, we have taken 50 cases of breast cancer patients compared with 50 age matched control women.[b] RESULTS[/b]: There were significant increase in the levels of MDA and significant decreases in the levels of antioxidants like GSH and Vitamin-C in breast cancer patients when compared with controls. There were also significant increase in the levels of Serum total cholesterol, triglycerides and LDL cholesterol and no statistical significant difference was observed with HDL cholesterol in cases when compared with controls. There was significant increase in the levels of homocysteine levels in cases when compared with controls. [b]CONCLUSION[/b]: Our results indicate that oxidative stress and alterations in lipid profile and homocysteine levels are associated with the development of breast cancer and the need for modification of lifestyle for the reduction of breast cancer development.
Authors and Affiliations
Hareesh G. S. R, Neelima Parlapalli, Kedari G. S. R
HYPOCALCAEMIA DUE TO PHOTOTHERAPY IN TERM NEONATES WITH NEONATAL HYPERBILIRUBINEMIA
BACKGROUND Jaundice is an important problem in the first week of life.1,2 It is a cause for concern for the physician and a source of anxiety for the parents. High bilirubin level may be toxic to the developing central n...
LIPOMA OF THE SUBMANDIBULAR SPACE
Lipomas in the submandibular space are uncommon. This report describes a case of lipoma in the submandibular space. The clinical features, imaging study, histopathological features and management of the tumour,...
TO DETERMINE THE USE OF AN LNG-IUS FOR CONSERVATIVE MANAGEMENT IN WOMEN WITH SYMPTOMATIC MILD TO MODERATE ENDOMETRIOSIS
Medical treatment of endometriosis, a condition which significantly affects the quality of life in only 10–15% of women in the reproductive years, rest have no improvement. Although oral progestogens are effect...
A PROSPECTIVE OBSERVATIONAL STUDY ON PREDICTION OF PREECLAMPSIA IN EARLY PREGNANCY BY SPOT URINE PROTEIN-CREATININE RATIO
BACKGROUND Hypertension and proteinuria are minimum criteria to diagnose preeclampsia. Proteinuria is called significant when there is excretion of more than or equal to 300 mg of urinary protein in 24 hrs. period. Even...
EFFICACY OF MAGNESIUM SULPHATE AS ADJUVANT TO BUPIVACAINE FOR LOCAL WOUND INFILTRATION FOLLOWING ELECTIVE ABDOMINAL SURGERIES
BACKGROUND Aims- Effective postoperative pain management minimises patient’s suffering, facilitates rapid recovery, allowing early discharge from hospital and decreases hospital cost. This study compares analgesic effica...