A Case of Long Term Survival in Woman with Metastatic Breast Cancer Treated with Trastuzumab
Journal Title: Journal of IMAB - Annual Proceeding (Scientific Papers) - Year 2012, Vol 18, Issue 1
Abstract
Intravenous Trastuzumab is an effective treatment for metastatic breast cancer after failure of first- line chemotherapy for patients with human epidermal growth factor 2 (HER- 2) - positive receptor. The aim of this study is to present of case of long time survival woman with metastatic breast cancer. The case is a 55- years old female. She underwent left mastectomy with axillary lymphadenectomy for breast cancer. Histological examination showed invasive ductal carcinoma, grade III, estrogen and progesterone receptor- negative, HER2- positive receptor status. Radiotherapy and six courses with antracyclines were performed as adjuvant chemotherapy. One year after the operation she was diagnosed to have lung metastases. Treatment was initiated with Trastuzumab 8 mg/kg for loading dose and 4 mg/kg maintenance dose every week. Treatment was continued for more than two years. Control computer tomography indicates stable disease. No adverse events were reported for twenty four months of Trastuzumab treatment. Treatment was stopped due to patients withdrawn. Overall survival was 31 months. This case indicate that long term Trastuzumab would be an optimal treatment for HER2- positive breast cancer patients.
Authors and Affiliations
Deyan Davidov
Keywords
Related Articles
- EP ID EP151295
- DOI 10.5272/jimab.2012181.213
- Views 107
- Downloads 0
FOLIC ACID AND VITAMIN B12 LEVELS IN BULGARIAN PATIENTS WITH BURNING MOUTH SYNDROME.
Actually the burning mouth syndrome (BMS) can be classified as idiopathic and secondary. The deficiency of vitamins (especially the group B) can be involved in BMS. In a group of 92 consecutive Bulgarian patients without...
LIFE EVENTS WITH STRESSFUL EFFECT ON PATIENTS WITH SCHIZOPHRENIA ACCORDING TO THE SEX AND AGE.
According to the literature life events with stressful effect are significant both for initiation and progress of the schizophrenia. Having this in mind we set our aim to be investigating the relationship between life ev...
MULTIPLE OCCUPATIONAL SENSITIZATION IN DENTAL PROFESSIONALS AND DENTAL STUDENTS ALLERGIC TO FORMALDEHYDE AND/OR GLUTARALDEHYDE.
Purpose: In dental practice is common concomitant exposure to formaldehyde andglutaraldehyde. Formaldehyde is an ingredient of some dental materials and may bereleased from methacrylate-based dental materials. A multitud...
A CURRENT 4-YEARS RETROSPECTIVE SURVEY OF 64 SURGICALLY TREATED ZYGOMA COMPLEX FRACTURES IN DEPARTMENT OF MAXILLO-FACIAL SURGERY, UNIVERSITY HOSPITAL ‘ST. ANNA’, SOFIA, BULGARIA.
Purpose: The goal of this material was to be an example of the complications that can occur in cases of zygoma fractures and to draw the attention of the clinicians to the need of accurate diagnose and early treatm...
ADRENAL ONCOCYTOMA IN CHILDREN – case report
Adrenal oncocytomas are usually non functional and hence incidentally detected. Most of these adrenal neoplasms are benign. Functioning adrenocortical oncocytomas are extremely rare and most reported patients are between...