A Comparative Study of Antinociceptive Activity of Fluoxetine with Diclofenac in a Rodent Model
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 3
Abstract
Antidepressants like fluoxetine have been shown to have analgesic activity with superior safety profile and hence might be better suited in the management of chronic pain. OBJECTIVES OF THE STUDY 1) To evaluate the analgesic activity of fluoxetine. 2) To compare the analgesic effect of fluoxetine with diclofenac. METHODOLOGY : Adult albino rats of either sex were used in this study. Screening method used was Eddy’s hot plate method.Rats were divided into three groups of 5 animals for above mentioned method and drugs administered as follows: Group-1: Distilled water (control) Group-2: Fluoxetine Group-3: Diclofenac Statistical analysis was done by using one way-Analysis of variance (one way ANOVA) followed by TukeyKramer test. RESULTS : Fluoxetine showed significant analgesic activity in hotplate method, but it was less significant than that of diclofenac.
Authors and Affiliations
Dr. Manjunatha. C. H* , , Dr. Jagadish Ratnakar. S,
Keywords
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