A Comparison of GFR by Cockcroft-Gault Equations and Gates method for estimating Glomerular Filtration Rate in Chronic Kidney Disease Patients.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 2
Abstract
The gamma camera uptake method with 99m Technetium labeled Diethylene Triamine Penta Acetic acid (Tc-DTPA) is simple and less time consuming for determination of glomerular filtration rate (GFR).Predicted creatinine clearance methods were compared with Gates method using 99m Tc-DTPA formeasurement of GFR.99mTc-DTPA renography was performed on 92 patients (72 men and 20 women, age range being 21 to 72 years) with wide range of renal function. The GFR was determined simultaneously by two methods,(a)Gamma camera uptake (Gates),(b)Predicted creatinine clearance methods: (i) Cockcroft-Gault (CG) and (ii) Modification of Diet in Renal Disease (MDRD). The Gamma camera uptake method was chosen as a reference. For GFR <15ml/min/1.73m2, there were no formulae correlated with isotopic GFR (iGFR). The MDRD equation was found to correlated with iGFR when GFR ranges16-29 ml/min/1.73m2 (P=0.0004) and GFR ranged from 30-59 ml/min/1.73m2 (P=0.0001). The CG formula was correlated with iGFR (P=0.0172) when GFR ranges from 60-89 ml/min/1.73m2.CG estimate of GFR predicts renal function in patients with chronic kidney disease (CKD) in normal GFR range (>60 ml/min/1.73m2). The MDRD equation estimated that the GFR predicts renal function in patients with CKD when GFR range from (16 to 60 ml/min/1.73m2). There are no formulae that predicts GFR<15 ml/min/1.73m2.
Authors and Affiliations
DR. SRABONI SEN , DR. ARUNA BHATTACHARYA
Keywords
Related Articles
- EP ID EP158466
- DOI -
- Views 94
- Downloads 0
Topic Name – Nail Lacquers in Nail Diseases
: Fungal infections of skin are one of the most common infections in human beings. The areas which are likely to get infected include the scalp, the hands and the feet. Dermatophytes, yeasts and moulds are the th...
Ochratoxinogenic fungi And Ochratoxin A contamination Of Cocoa Beans
Introduction:Ochratoxin A is a mycotoxin produced by Aspergillus and Penicilliumfungi. It is a food contaminant found in cereals, coffee, dried fruits, beer, wine, and cocoa. The aim of this study was to identify potenti...
Reducing Uveitic Glaucoma: therapeutic judgement is the key
Background: Uveitic glaucoma (UG) due to disease and /or therapeutics is an important reason for reduced vision. Different therapeutic regimen employed in uveitis can alter the course of UG. Purpose: Evaluatio...
Development and validation of GC-MS method for analysis of chloropyramine hydrochloride in ointments
A simple, rapid, sensitive, specific, accurate, and reproducible method for the determination of chloropyramine hydrochloride in ointments based on gas chromatography – mass spectrometry detection was develop...
GC-MS Analysis of the Polyherbal Mixture
The aim of the study was to investigate the phytoconstituents of chloroform extract of polyherbal mixture containing Argemone mexicana leaves, Echinops echinatus roots and Tricholepis glaberrima aerial parts using GC-MS...