A HISTOMORPHOLOGICAL STUDY OF PAEDIATRIC ADRENAL TUMOURS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 22
Abstract
BACKGROUND: Tumors of the adrenal gland are extremely rare in children. Those of the adrenal cortex account for only 0.3-0.4 % of all childhood neoplasms. Its rarity has hindered the identification of meaningful prognostic factors. Because very few children have been treated for adrenal tumors, even at major cancer centers, clinical experience is relatively limited and optimal therapy has not been established. Even though assessment of malignancy through histological criteria has been controversial, several investigators reported high degree of accuracy in the evaluation of malignancy by microscopic examination(1, 2). Furthermore, Bugg et al reported that histological type and tumour weight were the most reliable predictors of tumour behaviour in the paediatric age group. AIM: To analyze various adrenal tumors based on histopathological pattern and correlate with clinical findings. [b]MATERIALS AND METHODS[/b]: The study included 12 surgical specimens of adrenal gland out of which 3 were resected and 9 were biopsied specimens, collected between JULY 2006 to JUNE 2011 at Institute of Child Health, Niloufer hospital , Hyderabad. Tissues were processed and histopathological patterns were studied on Hematoxylin and Eosin stained sections. Immuno histochemistry was done in relevant cases and the markers used were Ki-67, Synaptophysin, NSE, Chromogranin. [b]RESULT[/b]: The study showed incidence of 75% in male and 25% in female children with predilection towards left adrenal gland.
Authors and Affiliations
Ramani M, Radhika Krishna, Geetha K, Ramesh Reddy, Sreenivas Reddy, Chandu Revathi, Ibraheem Javeed, Puja Deshmukh
Keywords
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