A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2015, Vol 5, Issue 2
Abstract
Background: Nearly all smokers show some evidence of lung and systemic cellular and/or humoral inflammation, only a few will experience an amplified response and develop chronic obstructive pulmonary disease (COPD). Several studies have shown systemic inflammation in COPD patients with increased neutrophil, macrophage and T lymphocyte numbers, and high concentrations of inflammatory mediators in peripheral blood (C-reactive protein, interleukin (IL)-6, IL-8, and tumor necrosis factor- (TNF-)). Aims and Objective: To study oxidative stress, antioxidant status, and TNF- levels in patients with COPD. Materials and Methods: Forty-four COPD patients along with an equal number of age- and sex-matched controls were included in study. The levels of malondialdehyde (MDA; by thiobarbituric acid assay), assay of TNF- (by TNF-), and total antioxidant were measured. Results: Malondialdehyde level was found to be significantly higher in all cases, and it was statistically significant in COPD patients with Global Initiative on Obstructive Lung Disease (GOLD) classification grades 2 and 3. Total antioxidant level was significantly lower in all the patients with COPD and was statistically significant in GOLD grades 2 and 3. Like MDA, TNF level was also significantly higher in all the cases with statistically significant increase in GOLD grades 2 and 3. Conclusion: To better understand the role of these trace elements and oxidative stress in the pathogenesis and complications of COPD, it is recommended to carry out further clinical studies.
Authors and Affiliations
Arun K Singh, Lalit P Meena, Arun Saravanan, Ravi Tandon
Keywords
Related Articles
- EP ID EP96165
- DOI 10.5455/njppp.2015.5.230920141
- Views 105
- Downloads 0
Variation and association of body mass index with myocardial oxygen consumption: A gender based study in young population
Background: Regular exercise improves health and prevents many diseases. Exercise testing can be used as a diagnostic tool to unmask subclinical conditions such as coronary artery diseases and also monitor the eff...
Assessment of cadmium and lead concentrations in different types of cosmetics products consumed in Iran
Background: A safety assessment of cosmetic is necessary for evaluating the health risks associated with the use of these products. Aims and Objectives: The aim of this study is to assess the cadmium (Cd) and lead (Pb) c...
Menkes disease - A rare case report
Menkes disease (MD) is a rare, lethal multisystemic disorder of copper metabolism characterized by cerebral and cerebellar neurodegeneration, fair skin with peculiar “kinky hair” and connective tissue abnormalities. It i...
Visual evoked potential changes among security guards of Government Medical College and New Civil Hospital, Surat
Background: Sleep interruption and disturbance of circadian rhythm are inevitable phenomena among night shift workers. A very few evidence is available that describing effects of sleep disturbance and its effect on the v...
The use of reversibility percent in spirometric assessment of chronic obstructive pulmonary diseases for the detrimental effect of 3rd generation beta-blockers
Background: For clinicians who work in respiratory medicine, the use of beta-blockers (BBs) has, for a long time, posed a dilemma because of the potential risk of bronchospasm and neutralization of the effectiveness of β...