ACCURACY OF MALARIA DIAGNOSIS AND PRESCRIBING PATTERNS FOR FEBRILE UNDERFIVES IN AN AREA WITH DECLINING MALARIA BURDEN, NORTHEASTERN TANZANIA
Journal Title: Asian J of Pharm Sci & Tech - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT This study examined the accuracy of clinical diagnosis and rapid malaria diagnostic test (mRDT) for the prediction of malaria; and the patterns of prescription for febrile underfives in a setting with reduced malaria burden. A quantitative facility based study was carried among 510 febrile underfives attending in primary health facilities of Tanga city. For each underfives referred for laboratory malaria confirmation; fever was measured by a digital thermometer and finger prick blood samples taken for mRDT testing and microscopy. Results of mRDT were provided to the clinician for a prescription and type of drugs prescribed recorded. Accuracy of measured fever, clinical diagnosis and mRDT for the prediction of malaria was assessed by performance indices against microscopy. Influence of mRDT results on prescribing patterns was also assessed. A clinical malaria diagnosis had a very highly sensitivity (100% [95%CI: 87.0 – 100.0]) and negative predictive value (100.0% [95%CI: 98.7 – 100.0]); but a relatively low specificity (74.0% [95%CI: 70.0 – 77.8]) and very low positive predictive value (21.0% [95%CI: 15.1 – 28.4]). The mRDT retained very high sensitivity ≥ 95.0% (97.0% [95%CI: 84.2 – 99.5]), specificity was also high (93.9 % [95%CI: 91.4 – 95.9]) but below the WHO recommendation of ≥ 95%. Of the 162 receiving antimalarial, only 21.6% were mRDT positive while majority (78.4%) was mRDT negative. Of those receiving antibiotic, the large majority (93.0%) was mRDT negative probably representing an over prescription of antibiotics. The decline in malaria prevalence has altered the performance of mRDT to a specificity < 95% below the WHO recommendation. There was an over prescription of both antimalarial and antibiotics. Key words: Febrile underfives, Diagnostic accuracy, mRDT, Prescribing patterns, Tanzania.
Authors and Affiliations
Donath Samuel Tarimo, Dominic Emilio Shauri, Ahmed Abade Mohamed
Keywords
Related Articles
- EP ID EP144097
- DOI -
- Views 138
- Downloads 0
AGRICULTURAL WEEDS AS MEDICINAL PLANTS OF KADAPA DISTRICT, A.P., INDIA.
ABSTRACT A weed is an unwanted plant growth in a place where some other plants are also growing or no other plant has to grown at all. The plants growing in a wrong place i.e. in agriculture fields are often refe...
IN SILICO DESIGN AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDYL TRIAZOLE DERIVATIVES AS COX-2 INHIBITORS
ABSTRACT Molecular docking is used to predict and analyze interactions between protein receptors and ligands. In the present investigation novel substituted pyridyl triazoles are incorporated into benzothiazole a...
SSYNTHESIS CHARACTERIZATION AND COMPARATIVE STUDIES OF TURMERIC OLEORESIN DERIVED FROM SELECTED TURMERIC PLANTS
ABSTRACT This paper reports an investigation of the extraction of Oleoresin present in the crude plant extracts of four selected turmeric plants i.e. BSR-01, BSR-02, CL-101, CL-219. Oleoresin is one of the most s...
EFFECT OF AMMONIUM NITRATE AND PHOTOPERIOD ON IN VITRO MICRORHIZOME INDUCTION IN THREE HIGH YIELDING CULTIVARS OF CURCUMA LONGA L. AND THEIR COMPARATIVE PHYTOCHEMICAL ANALYSIS
ABSTRACT Turmeric- Curcuma longa L. of zingiberaceae, is one of the major medicinal spice crop in India. Microrhizome induction is a novel biotechnological tool to produce disease free planting materials in this...
CHEMICAL CONSTITUENTS AND PHARMACOLOGICAL EFFECTS OF ASTRAGALUS HAMOSUS AND ASTRAGALUS TRIBULOIDES GROWN IN IRAQ
ABSTRACT Two members of Astragalus genus grown in Iraq, Astragalus hamosus and Astragalus tribuloides. They possessed a wide range of pharmacological effects. This review highlight the chemical constituents and p...