Analgesic activity of alkyl piperidine derivatives
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 1
Abstract
Piperidine is the most significant scaffold which reveals therapeutic potential because of its conformationally flexible nature. During the course of present investigations synthetic quaternary salts of alkyl piperidine with various phenacyl bromides were explored for their possible analgesic activity. Compounds I analogs (1a-1f) and compound II analogs (IIa-IIf) showed varying degree of analgesic activity when compared with pethidine as standard and its duration by tail immersion method.
Authors and Affiliations
Sarwat Jahan , Shamim Akhtar , Arfa Kamil , Nousheen Mushtaq , Zafar Saied Saify , Muhammad Arif
Keywords
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