ANTIBIOTIC SUSCEPTIBILITY PATTERN OF KLEBSIELLA PNEUMONIAE ISOLATED FROM CASES OF URINARY TRACT INFECTION IN A TERTIARY CARE SETUP
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 29
Abstract
Urinary Tract Infection (UTI) is second on the ranking of most common infection in community practice. It leads to significant morbidity and a high economic burden for treatment. Klebsiella pneumoniae accounts for 2nd highest organism isolated from urine samples of UTI patients after Escherichia coli. The management of UTI is complicated by the increasing prevalence of antibiotic resistant strains of Klebsiella pneumonia. Therefore, knowledge of the antibiotic resistance patterns of the pathogen is important not only to provide an appropriate therapy, but also for the prevention of resistance amongst the microbe. OBJECTIVE The present study was therefore undertaken to determine the antibiotic susceptibility pattern of Klebsiella pneumonia causing UTI in patients admitted to a tertiary care hospital. MATERIAL AND METHODS The details of Klebsiella pneumonia grown in urine samples received in the Department of Microbiology, MOSC Medical College, were collected from the laboratory registers. These urine samples were then processed using standard methods and antibiotic susceptibility testing was done by Kirby Bauer’s disc diffusion method. RESULT During the period of 4 months, 35 urine samples yielding Klebsiella pneumonia were processed. These strains showed 100% resistance to Ampicillin, around 70–85% resistance to first, second and third generation Cephalosporins. They showed maximum sensitivity to Imipenem (74.3%), followed by Colistin (77%), Amikacin (65.7%), Meropenem (65.7%) and Piperacillin-Tazobactam (65.7%). CONCLUSION In our study, the high rate of resistance to routinely prescribed drugs like Co-trimoxazole, Norfloxacin and Nitrofurantoin could be attributed to the frequent use of these antibiotics. Carbapenems (Imipenem or Meropenem) and Amikacin should be considered as reserved drugs, especially for nosocomial infections.
Authors and Affiliations
Anila , Shareen , Radhakuttyamma , Anna
Keywords
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- EP ID EP107187
- DOI 10.14260/jemds/2016/346
- Views 64
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