Approaches to develop PLGA based in situ gelling system with low initial burst
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
In situ gelling systems have gained much interest owing to their successful application in the preparation of controlled drug delivery and tissue engineering. The commonly used polymer for these systems is the biocompatible and biodegradable polymer of Poly (lactic-co-glycolic acid) (PLGA) that is available in the market as implants, microparticles and in situ implant. A polymeric solution is prepared by mixing the polymer with a biocompatible solvent which may be water miscible such as N-methyl pyrrolidone (NMP), 2-pyrrolidone and Dimethyl sulfoxide (DMSO) or partially water miscible solvents such as triacetin, benzyl benzoate, ethyl acetate, triethyl citrate and benzyl alcohol. Upon injection of this polymeric solution into buffer or physiological fluid, the system solidifies and the administered drug releases in a controlled manner. The major drawback of these systems is their high initial burst that characterized by release of a noticeable amount of the administered drug during the first release stage that usually results in drug toxicity and tissue irritation. This review focuses on presenting the different strategies utilized to decrease the initial burst from PLGA in situ gelling system.
Authors and Affiliations
Tarek Ahmed
Keywords
Related Articles
- EP ID EP127233
- DOI -
- Views 90
- Downloads 0
Antimicrobial, antitumor and brine shrimp lethality assay of Ranunculus arvensis L. extracts
To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE), Methanol-Water...
The characteristics of acromegalic patients with hyperprolactinemia and the differences with hyperprolactinemia patients
A substantial proportion of acromegalic patients have co-existent hyperprolactinaemia. To compare this group of population (AC+HPRL) to those of patients with merely hyperprolactinemia (HPRL), a retrospective analy...
Antibacterial, antioxidant, anti-cholinesterase potential and flavonol glycosides of Biscutella raphanifolia (Brassicaceae)
Different extracts of the aerial parts of Biscutella raphanifolia (Brassicaceae), which has not been the subject of any study, were screened for the phytochemical content, anti-microbial, antioxidant and anti-choli...
The correlation between the Glycated hemoglobin (HbA1c) in non-diabetics and cardiovascular risk factors
This study aimed to discuss the relativity between the glycated hemoglobin (HbA1c) in non-diabetics and cardiovascular risk factors and definite the significance of predicting the cardiovascular risk factors throug...
Synthesis, characterization and bioevaluation of technetium-99m labeled N-(2-Hydroxybenzyl)-2-amino-2-deoxy-D-glucose as a tumor imaging agent
N-(2-Hydroxybenzyl)-2-amino-2-deoxy-D-glucose (NHADG) was synthesized by conjugation of salicylaldehyde to glucosamine. The obtained compound was well characterized via different analytical techniques. Labeling of the sy...