CA-125 AS A SURROGATE MARKER IN A CLINICAL AND HISTOPATHOLOGICAL STUDY OF PELVIC MASS AT A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 26
Abstract
[b]Context[/b]- Pelvic masses are common in women of all age groups and their accurate diagnosis poses a clinical challenge because of atypical and non specific presentation. The combination approach of exploratory laparotomy and histopathological examination remains the corner stone for management. CA 125, a biomarker has been evaluated in several studies as a surrogate tool in these cases.[b] OBJECTIVES[/b]: To determine the diagnostic value of CA 125 in pelvic mass and to know its sensitivity and specificity in ovarian cancers. [b]MATERIAL AND METHODS[/b] – 80 patients suspected of pelvic mass at JSS Hospital, Mysore subjected to clinical examination, CA 125 detection and laparotomy followed by histopathological correlation. [b]RESULTS[/b]: CA 125 levels were seen to be more in large fibroids. High levels were recorded in extensive adenomyosis and endometrial carcinoma stage1A onwards. Sensitivity and specificity in post-menopausal women was 100% for malignant ovarian tumors. [b]CONCLUSION[/b] -CA 125 estimation can be used as an adjunct tool in the evaluation of pelvic mass and is a highly useful assay in the diagnosis of ovarian cancers in the post-menopausal women.
Authors and Affiliations
Madhuri Kulkarni, Ambarish Bhandiwad, Sunila R, Sumangala
Keywords
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- EP ID EP148664
- DOI 10.14260/jemds/911
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