Characterization of StyR-234 non-coding RNA in regulation of Multi-drug resistance in Salmonella enterica serovar typhi
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 1
Abstract
Non-protein coding RNAs (npcRNA) have been recently recognized in bacterial pathogens as a new group to regulate multi-drug resistance. Among several pathogenic bacterial spcecices, Salmonella enterica serovar Typhi (S. typhi) one of the focusing target in order to prevent severe impact in human health and it pose a problem by causing high fever. we report the characterization of StyR-234, a small antisense npcRNA, discovered from Salmonella typhi. StyR-234 is located on positive strand and antisense to, bacA gene. Since bacA is known to participate in MDR, we hypothesis StyR-234 is involve in bacA regulation thus could have role in drug resistance in S. typhi. Overexperssion analysis show that S. typhi became more susceptible to six antibiotics (Amikacin, Cefepime, Trimethoprim Sulphamethoxazole, Imipenem, Meropenem, Piperacillin Tazobactam) while more resistance to two antibiotics (Ampicillin and Cefotaxime). And no changes in sensitivity for three antibiotics (Ciprofloxacin, Clindamycin and Ceftazidime). The results indicated that StyR- 234 increasing susceptibility to many antibiotics could be by down regulating antibiotic resistant gene bacA.
Authors and Affiliations
Siventhiran Balakrishnan1 , Sheryna Kaur1 , Kishan raj1 , , Sunitha Paripelli2 , Sathyanarayana Namani2 , Suresh V. Chinni 2
Keywords
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