Clinical curative effect of oxaliplatin combined with flurouracil in the treatment of gastrointestinal tumor
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 3
Abstract
Aiming at exploring clinical curative effect of oxaliplatin combined with flurouracil in the treatment of gastrointestinal tumor, this study divided 60 patients with gastrointestinal tumor into control and observation groups, each containing 30 patients. The observation group was treated with oxaliplatin combined with flurouracil, while the control was treated with FOLFOX4, i.e., intravenously dropping 85mg/m2 Oxaliplatin (L-OHP), 200mg/m2 calcium folinate (CF) and intravenously injecting 400mg/m2 5-fluorouracil (5-Fu), and 600mg/m2 5-Fu; then continuously performing intravenous drop infusion for 22h, every two weeks for a cycle. Hypodermic injection of granulocyte colony-stimulating factor (G-CSF) was conducted immediately when leukocytes occurred the III, IV degree of inhibition. The observation results of curative effect and negative reaction indicated higher effective rate with 83.33% in the observation and 50.00% in the control. Besides, in the observation, negative reactions possessed 10.00% that was much lower than 33.33% in the control. Thereby, the conclusion reached that the treatment of gastrointestinal tumor with oxaliplatin combined with flurouracil was worth promoting.
Authors and Affiliations
Baodong Li , Yonggang Liu , Jinbang Wang , Dongli Xu , Weiyu Feng , Jing Zhuang
Keywords
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