CLINICOPATHOLOGICAL ASPECTS OF HODGKIN LYMPHOMA IN A SOUTH INDIAN CITY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 58
Abstract
Hodgkin Lymphoma (HL) is a malignant disease of B lymphocyte, characterized by the presence of diagnostic Reed-Sternberg cells in an appropriate cellular microenvironment WHO (2008) classification consists of Nodular Lymphocyte Predominant (NLP) and classical Hodgkin Lymphoma (cHL). It has a bimodal age distribution, more common in males. In developed countries, Nodular Sclerosis (NS) - cHL is more common in females as compared to other types. Newer insight into biology of tumour classifies NS-cHL as a distinct entity, while Mixed Cellularity (MC) - cHL and Lymphocyte Depleted (LD) - cHL are part of the same biologic spectrum. Lymphocyte Rich (LR) - cHL mimics NLP in morphology and Immunohistochemistry (IHC) is crucial for diagnosis. PURPOSE We aim to correlate the differences of clinicopathological features of HL with subtypes of HL. METHODS It is a retro-prospective study which included 30 cases, diagnosed and confirmed with IHC, as HL in the Department of Pathology, Kasturba Medical College, Mangalore. RESULTS We found that NS-cHL was the most common (15 cases) followed by MC-cHL and LD-cHL, which were equal in number (5 cases) and then LR-cHL (3 cases). There were no cases of NLPHL in our study. Mean age for NS-cHL, MC-cHL, LD-cHL and LR-cHL were 25 yrs., 30.5 yrs., 61.5 yrs. and 33 yrs. respectively. M:F ratio for NS-cHL and MC-cHL was 1.5:1 for LR-cHL it was 1:2 and LD was seen only in males. NS-cHL commonly involved lymph nodes above diaphragm and MC-cHL involved a single lymph node region. LR-cHL presented in early stages with no mediastinal involvement. LD-cHL presented mostly in stage III (75%) with generalized lymphadenopathy. CONCLUSIONS We concluded that NS-cHL showed male predominance similar to other subtypes in our study unlike in developed countries where more females are affected. LD-cHL was distinctively seen in males, older age and as high-stage disease
Authors and Affiliations
Nidhish , Radha Pai, Prachi , Kausalya Sahu
Keywords
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- EP ID EP112619
- DOI 10.14260/jemds/2016/910
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