Comparative cardiac toxicity in two treatment schedules of 5-FU/LV for colorectal carcinoma
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2013, Vol 26, Issue 5
Abstract
The purpose of the study is evaluation and assessment of parameters of cardiac toxicity in patients subjected to 5-FU based chemotherapy. Cardiac morbidity is a reported outcome in different 5FU/LV regimens; however none of them are definite or proximate. The bimonthly regimen of high dose leucovorin is reported to be less toxic and more effective as compared to the monthly regimen of low dose leucovorin. We report the detailed assessment of few cardiac parameter of toxicity in patients of advanced colorectal carcinoma subjected to two Schedules of high and low dose Folinic Acid, 5-Fluorouracil, bolus and continuous infusion. The correlation of elevated cardiac biomarkers, angina and hypertension is comparatively assessed in patients with normal general status, hyperglycemia and known cardiac disorders subjected to two different 5FU based chemotherapeutic regimen.
Authors and Affiliations
Rahila Najam, Nusrat Bano
Keywords
Related Articles
- EP ID EP125749
- DOI -
- Views 94
- Downloads 0
Shattering a myth: Whooping cough susceptible to antibiotics
Bordetella parapertussis is the causative agent of a milder form of pertussis or whooping cough. Little is reported about the antibiotic resistance patterns and mechanism of drug resistance of Bordetella parapertus...
Preparation, in-vitro and in-vivo characterization of transdermal patch containing glibenclamide and atenolol: A combinational approach
A novel aspiration in treatment of chronic disease like diabetes associated with other non communicable disease risk factors, such as hypertension is to provide greater therapeutic effect, overcome the side effects by co...
Antihepatotoxic effect of golden berry (Physalis peruviana Linn.) in carbon tetrachloride (CCl4) intoxicated rats
Liver is the main site in the body for intense metabolism and excretion. A number of chemicals and drugs which are used routinely cause liver damage. The present study investigates the antihepatotoxic effect of Phy...
Molecular bonding characteristics of Self-plasticized bamboo composites
Bamboo biomass fibers were gradually separated, prepared, and then self-plasticized for immune composites. The molecular bonding characteristics of the self-plasticized bamboo composites were investigated by Fourie...
Development paths of China’s agricultural Pharmaceutical industry under Eco-agriculture background
Using pesticides has double effects. On one hand, it contributes to pests control and regulates the growth of crops; On the other hand, it does harm to the environment. To develop ecological agriculture should not...