Complexation of β-sitosterol with tris (dibenzylideneacetone) dipalladium and its anti-microbial activity
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
β-sitosterol is a naturally occurring plant sterol (phytosterol) present in many fruits and vegetables. Scientific research has proven that β-sitosterol is helpful in maintaining the proper functioning of our body. Previously we described the complexation of β-sitosterol with trace metals (Mahmood et al., 2013). Trace metals after the formation of complex unable to absorb in the body and hence eliminated out from the body thus reducing metal toxicity (Marsha, 1996). The present article describes the complexation of β-sitosterol with Palladium (Pd) metal. Palladium is a toxic metal and due to polluted and hazardous environment traces of this metal can be transferred into the body, which is harmful for human health. Our aim is to make Pd-sterol complex so that this toxic metal (Pd) does not absorb in the body and hence excreted out from the body in the complex form. In order to form this complex β-sitosterol (Ib) is reacted with Tris (dibenzylideneacetone) dipalladium or [Pd2 (DBA)3] (Ia) in 2:1 ratio in an inert atmosphere and dimethylformamid (DMF) added as a solvent. The resulting complex [Pd2 (DBA)3.(β-sitosterol) (Ic) was identified by various spectroscopic techniques such as IR, Mass and 1H-NMR. This new organo metallic complex (Ic) also showed significant antibacterial and antifungal activity. The present work revealed that Pd-sterol complex does not only reduce metal toxicity but also helpful in minimizing bacterial and fungal infections present in the body. Our research also concluded that we must take plenty of fruits and vegetables in our diet so that natural plant sterol such as β-sitosterol can enhance our defense mechanism and maintain other functions of our body.
Authors and Affiliations
Talat Mahmood , Yasmeen Bibi , Raana Zafar , Aneela Wahab , Iffat Mahmood , Nuzhat Arshad , Sikandar Khan Sherwani
Keywords
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