Correlation of serum uric acid and serum creatinine in hypothyroidism
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2015, Vol 5, Issue 3
Abstract
Background: Hypothyroidism is a progressive disorder that presents with diverse degrees of thyroid failure and metabolic consequences. Purine metabolism can be affected by disturbance in thyroid hormones, which leads to alteration in the uric acid levels, leading to hyperuricemia and subsequently causing gout. Also, hemodynamic changes occur in hypothyroidism that leads to reduction in renal plasma flow and glomerular filtration rate, which also causes increase in the levels of serum uric acid and serum creatinine. Aims and Objective: To determine whether thyroid dysfunction, subclinical and overt, has deleterious effects on renal function. Materials and Methods: This was a cross-sectional study that comprised 108 individuals (56 cases and 52 controls; 52 men and 56 women) aged between 20 and 60 years. Case group comprised suspected cases of hypothyroidism. Serum TSH, T4, T3, uric acid, and creatinine were estimated after applying inclusion and exclusion criteria. Result: Uric acid and creatinine levels were significantly elevated in case group as compared to control group (7.09 ± 0.45 and 1.52 ± 0.16 mg/dL versus 4.08 ± 0.25 and 0.62 ± 0.05 mg/dL, respectively; p o 0.001). There was insignificant correlation between serum uric acid and creatinine levels with hypothyroidism (r = 0.185, p = 0.172 and r = 0.082, p = 0.550). Also, there was no significant correlation between serum uric acid and creatinine levels with the age in hypothyroidism (r = 0.143; p = 0.292 and r = -20.154; p = 0.257, respectively). Conclusion: Hypothyroidism causes significant increase in serum uric acid and creatinine levels. Therefore, we would emphasize the importance of the routine evaluation of serum uric acid and creatinine levels in patients with hypothyroidism
Authors and Affiliations
Simbita Marwah, Mihir Mehta, Hitesh Shah, Nilayangode Haridas, Amit Trivedi
Galvanic skin resistance in different phases of menstrual cycle in acne vulgaris
Background: Galvanic skin response (GSR) is altered by sympathetic dominance and increased sympathetic activity will cause decrease in GSR. Skin conductance varies with different phases of menstrual cycle. Measuring skin...
A study on antidepressant-like effect of dihydroxy flavones in mice and their mechanisms involved
Background: In the treatment of depression, drugs with a quick onset of action and high margin of safety are intensely being searched. Previous studies indicate flavonoids as a potential source for such drugs. Hence, in...
Patient-based integrated teaching program with the inclusion of psychomotor and affective domains
Background: Integrated teaching program (ITP) is a solution to the compartmentalized teaching of fragmented and passive learning. However, ITP is conducted mainly in the form of lectures, whereas in our study, we have in...
A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital
Background: The prevalence of iron deficiency anemia (IDA) is 58% among pregnant women in developing countries. According to the recent national guidelines, intramuscular iron sorbitol citric acid (ISCA) complex is one o...
Simple visual reaction time in sickle cell disease patients of pediatric age group
Background: Reaction time (RT) test can be simple or choice or recognition type. RT test has been widely used in literature, but the changes seen, if any is not documented in pediatric age group of sickle cell patients....