Counter effects of N. Sativa L. and P. ovataL. on indicative markers ofnon alcoholic fatty liver disease
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 1
Abstract
The broad spectrum of non-alcoholic fatty liver disease (NAFLD) diseases ranges from simple liver inflammation to steatosis, leading to fibrosis and cirrhosis. Four groups of weaning (30g) Rattusnorvegicus were designated as W-0, W-I, W-II and W-III. For sixteen weeks group W-0 was given standard pallet diet, group I consumed diet “A” (20% fat Sucrose + 33% tea whitener + 34% ground pallet diet +13% water), group W-II was fed on diet “B” (50g Nigella sativa seeds/kg of A) and group W-III was provided with diet “C” (50g Plantagoovatahusks /Kg of A). The analysis of CBC, LFTs, and Lipid profile revealed that there were highly significant changes (P<0.001) in the MCV, PLT, Hb, MCH, MCHC, RBC, RDW%, WBC, MPV, Triglycerides, cholesterol, LDL and the significant alterations (P<0.01) in albumin, AST, bilirubin, AST/ALT, HDL and cholesterol/HDL were observed in the experimental groups when compared with control by using one way ANOVA. We concluded that high-energy diet can alter the blood profile. Moreover fat plummeting agents have counter impact on the hematology as well as serology of diet induced NAFLD in R. norvegicus.
Authors and Affiliations
Afshan Syed Abbas , Nadeem Sheikh
Keywords
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