DESIGN AND IN-VITRO-IN-VIVO CHARACTERIZATION OF BUCCAL TABLETS OF SIMVASTATIN
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 3
Abstract
ABSTRACT The main objective of present study is to develop Bucco adhesive bilayer tablets of Simvastatin using mucoadhesive polymers. Simvastatin has short biological half-life (3h), high first-pass metabolism and poor oral bioavailability (5%), hence an ideal candidate for buccal delivery system. The tablets were prepared by direct compression technique using carbopol-934, sodium carboxy methyl cellulose (Na CMC), Poly vinyl pyrollidine (PVP) and hydroxyl propyl methyl cellulose (HPMC) as mucoadhesive polymers. Soyabean powder is mainly used as a diluent in this formulation as it contain less fats and more protein substances. Formulations were evaluated for weight variation, hardness, friability, drug content, swelling studies, surface pH, bioadhesion strength, invitro drug release, ex-vivo permeation studies, using sheep buccal mucosa, muco irritation test, in-vitro release studies, in-vivo studies, IVIVC and stability studies. Formulation S11 exhibited controlled drug release at (11h) containing polymers like HPMC K100M, carbopol934P and PVP K30. Formulation S11 selected as optimized formulation based on physicochemical parameters and ex-vivo permeation studies and follows zero order drug release. FTIR studies show no evidence on interaction between drug, polymers and other excipients. The results indicate that Simvastatin is a suitable candidate when given through the buccal drug delivery. Key words: Mucoadhesion, Simvastatin, swelling index, buccal drug delivery.
Authors and Affiliations
M. Alagusundaram*, S. Angalaparameswai, M. Padmavathamma
Keywords
Related Articles
- EP ID EP90883
- DOI -
- Views 256
- Downloads 0
INTERCROPPING OF AYURVEDIC HERBS USEFUL IN THE MANAGEMENT OF DIABETES- A LIFESTYLE DISEASE
ABSTRACT A vibrant trade in herbal sector has resulted to consider issues related to conservation and cultivation of medicinal plants which are having high demand among patient population and pharma industry. The...
ESTIMATION OF BIOCHEMICAL COMPOSITION OF PURPLE SEA URCHIN (SALMACIS VIRGULATA, L.AGASSIZ AND DESOR, 1846)
ABSTRACT The proximate composition, fatty acids, minerals and vitamins contents of purple sea urchin (Salmacis virgulata) from the spine, viscera, test region of the S. virgulata analysed. Among the different tis...
A CRITICAL APPRAISAL OF RATIONAL & IRRATIONAL FIXED DRUG COMBINATIONS
ABSTRACT Fixed dose combinations (FDCs) is a combination product of two or more drugs in a single dosage form. Only some of the FDCs are rational and justified. . Various advantages of fixed Drug combination (FDC...
SCREENING OF EFFICACY OF VARIOUS EXTRACTS OF CARICA PAPAYA L. FOR POTENTIAL ANTIFERTILITY ACTIVITY
ABSTRACT This study was undertaken due to the popular belief in most of the Asian countries that the unripe fruit eaten during early months of pregnancy can lead to miscarriage. The aim of the present study was t...
CURRENT REGULATIONS FOR MARKETING AUTHORIZATION OF HUMAN GENERIC PRODUCTS GLOBALLY AS PER WHO
ABSTRACT Generic medicines are those where patent protection has expired, and which may be produced by manufacturers other than the innovator company. Use of generic medicines has been increasing in recent years,...