Detection and adequacy assessment of erythrocyte glutathione transferase on the cycle toxin level of hemodialysis patient
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 5
Abstract
To explore detection and adequacy evaluation of erythrocyte glutathione S transferase (GST) in hemodialysis patients on circular toxin levels, this paper divided 84cases of long-term hemodialysis end-stage patients into 33 cases of adequate hemodialysis group (spKt/V≥1.3) and 51 cases of inadequate hemodialysis group (spKt/V<1.3) according to urea index value of unit chamber model (spKt/V). Take the other 50 cases of healthy physical examination people for control group, compare and analyze related clinical and biochemical indexes differences of three groups. The level of hemodialysis group GST, creatinine, high sensitivity C-reactive protein (hs-CRP), transferrin saturation (TSAT), parathyroid hormone (PTH), interleukin-2,6,8 (IL-2,6,8) and tumor necrosis factor-α (TNF-α) was significantly higher than the control group (P<0.05), and GST, IL-2, 6, 8, TNF-α level of inadequate hemodialysis group was significantly higher than adequate hemodialysis group (P<0.05). Pearson’s relevant analysis showed that GST and spKt/V, IL-2, IL-6, IL-8, TNF-α have positive correlation (P<0.05) and had no correlation with creatinine, hs-CRP, TSAT, PHT (P>0.05). There was 23patients spKt/V≥1.3 after adjusting the dialysis solution for 51cases of inadequate hemodialysis patients, GST level after the adjustment was significantly lower than before the adjustment, but still higher than adequate dialysis group. It concludes that the maintenance of hemodialysis patients’ level has certain relevance on spKt/V and associated inflammatory factors. Through the determination, GST can effectively response the adequate hemodialysis, which has a guiding significance on adjusting blood dialysis solution in clinic.
Authors and Affiliations
Hui Qiu , Dewei Zhang , Ping Huo , Min Hong , Hongguang Zheng
Keywords
Related Articles
- EP ID EP122823
- DOI -
- Views 109
- Downloads 0
Salmon calcitonin in the treatment of elderly women with type 2 diabetes complicated with osteoporosis
To explore the reasonable treatment scheme of salmon calciteonin in the treatment of elderly women with type 2 diabetes complicated with osteoporosis, patients were randomly divided into Group A, B and C, and they...
Mutagenic breeding of Quambalaria cyanescens strain for the production of milk-clotting enzymes
A strain for producing rennet was screened from red kojic rice and identified as Quambalaria cyanescens. In the current work, various mutagenic treatments, such as UV, diethyl sulfate and their combinations were ap...
Measures of reducing obstetric emergencies hysterectomy incidence
To study the obstetric emergency hysterectomy which can reduce the incidence of measures. In maternity of Xinxiang Central Hospital, the total number of deliveries cases has been up to 50,526 in 20 years, of which...
Study of the effect of inorganic and organic complexes of arsenic metal on the status of GSH in T. cells and B. cells of blood
Arsenic is a major threat to large part of the population due to its carcinogenic nature. The toxicity of Arsenic varies with its chemical form and oxidation states. Glutathione (GSH), a major intra-cellular tripep...
Exogenetic insulin increased bone mineral densityin middle-aged male patients with type 2 diabetes mellitus
We aimed to evaluate the influence of exogenetic insulin on bone mineral density (BMD) in Type 2 Diabetes Mellitus (T2DM). Group A included 120 cases of middle-aged male patients with type 2 diabetes mellitus were...