Determination of HOMA IR cut off value, and efficiency of lipids and lipoprotein ratios as discriminator of insulin resistance in type 2 Diabetes Mellitus patients
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 6
Abstract
Insulin resistance has a central role, not only to predict the future development of type 2 diabetes and incident cardiovascular diseases; as well as can be used as a therapeutic target after hyperglycemia is diagnosed. The use of surrogate markers therefore be useful to know the status of insulin resistance. The HOMA IR can perform same function, and the ratios calculated from the lipids and lipoprotein may also be useful to know the status of the insulin resistance in type 2 diabetic patients. In the present study 150 type 2 diabetic subjects and 150 age & sex matched healthy controls were included, to find the cut off value of HOMA IR as well as lipid & lipoprotein ratios to predict insulin resistance. The ROC curve analysis gave the cut off value of >2.41 for HOMA IR with highest sensitivity and specificity, further type 2 diabetics were divided on the basis of cut off value of HOMA IR from present study. Significant increases in TG, VLDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios were found in patients with HOMA IR cut off value of >2.41 than with HOMA IR cut off value of ≤ 2.41. Also the ROC curve analysis for lipids and lipoproteins indicated that, TC, TG, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, CRF and Non HDL-C serves the better discriminator for insulin resistance. Therefore, the lipoprotein ratios along with the lipid and lipoprotein levels may be used as markers for insulin resistance.
Authors and Affiliations
Momin AA1*, Bankar MP2, Bhoite GM3
Keywords
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