Diagnostic Efficacy of Modified Coagglutination Test in the Diagnosis of Human Brucellosis
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2013, Vol 2, Issue 2
Abstract
Background: Laboratory help is must for thediagnosis of human brucellosis due to proteanclinical manifestations. As culture is hazardous,time consuming and less sensitive, serologicaltests are preferred for the diagnosis. Agglutinationtests like Rose Bengal PlateTest (RBPT), Serum Agglutination tests (SAT),2-Mercaptoethanol test (2-ME) that are commonlyemployed for the diagnosis either lacksensitivity or specificity. Coombs test andBrucellacapt though are sensitive and specific,workout costly. Therefore, modifiedcoagglutination test was developed and its diagnosticefficacy was evaluated. Aims and Objectives:To develop modified coagglutinationtest for the diagnosis of human brucellosis andcompare it with Coombs test. Materials andMethods: Serum samples collected from 191brucellosis patients and 100 controls were subjectedto 2-ME, Coombs test and modifiedcoagglutination test (MCOAG). Blood culturewas performed by Castanedas method in all thepatients. Results: Significant difference in thepositivity rate was seen between MCOAG and2-ME. The results of MCOAG were comparablewith Coombs test. Conclusions: Modifiedcoagglutination test is a better option toCoombs test for the serodiagnosis of brucellosisin resource constrained countries as it issensitive, specific and cost effective.
Authors and Affiliations
Smita S Mangalgi , Annapurna Sajjan , Mohite S. T
Keywords
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