Dynamic matching algorithm for viral structure prediction
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 4
Abstract
Most viruses have RNA genomes, their biological functions are expressed more by folded architecture than by sequence. Among the various RNA structures, pseudoknots are the most typical. In general, RNA secondary structures prediction doesn’t contain pseudoknots because of its difficulty in modeling. Here we present an algorithm of dynamic matching to predict RNA secondary structures with pseudoknots by combining the merits of comparative and thermodynamic approaches. We have tested and verified our algorithm on some viral RNA. Comparisons show that our algorithm and loop matching method has similar accuracy and time complexity, and are more sensitive than the maximum weighted matching method and Rivas algorithm. Among the four methods, our algorithm has the best prediction specificity. The results show that our algorithm is more reliable and efficient than the other methods.
Authors and Affiliations
Hengwu Li , Daming Zhu , Caiming Zhang , Zhengdong Liu , Huijian Han , Zhenzhong Xu
Keywords
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