EFFECT OF ETHANOLIC EXTRACT OF FLOWERS OF TECOMA STANS ON ACETIC ACID INDUCED COLITIS IN ALBINO RATS
Journal Title: Asian J of Pharm Sci & Tech - Year 2014, Vol 4, Issue 2
Abstract
ABSTRACT Aim to evaluate the effect of ethanolic extract of flowers of Tecoma stans on acetic acid induced colitis in albino rats. Ethanolic extract of Tecoma stans (EETS) was prepared by percolation method. Acute toxicity test was done by using Organization for Economic Cooperation and Development guidelines. Albino rats were divided into four groups of five animals each. Groups A and B received 3% gum acacia. Groups C and D received EETS 500 mg/kg body weight (BW) and 5- aminosalisylic acid 100 mg/kg BW respectively. Colitis was induced by transrectal administration of 4% acetic acid on 5 th day. All animals were sacrificed after 48 h of colitis induction and distal 10 cm of the colon was dissected. Colon was weighed for disease activity index (DAI) and scored macroscopically and microscopically. Biochemical assessment of tissue myeloperoxidase (MPO), catalase (CAT) and superoxide dismutase (SOD) was done in colonic tissue homogenate and malondialdehyde (MDA) was estimated in serum. T.stans showed significant (P < 0.05) reduction in DAI, macroscopic and microscopic lesion score as well as significant (P < 0.05) improvement in MPO, MDA, CAT, and SOD level as compared to Group B. The ethanolic extract of flowers of T.stans showed significant amelioration of experimentally induced colitis, which may be attributed to its antiinflammatory and antioxidant property. Key words: Antioxidant, Colitis, Tecoma stans.
Authors and Affiliations
S. Kameshwaran*, R. Senthil Kumar, S. Thenmozhi, M. Dhanalakshmi, K. Vasuki, K. Manjuladevi
Keywords
Related Articles
- EP ID EP138839
- DOI -
- Views 115
- Downloads 0
TESTOESTERONE DEFICIENCY IN UNDER 40 YEARS PATIENTS OF DIABETES MELLITUS
ABSTRACT Diabetes is a chronic disease that occurs when the pancreas does not produce enough insulin (a hormone that regulates blood sugar) or alternatively, when the body cannot effectively use the insulin it pr...
REVIEW OF ELECTRO PHOTONIC CAPTURING (EPC) METHOD TO MEASURE THE ACTIVITY OF THE AUTONOMOUS NERVOUS SYSTEM
ABSTRACT EPC is a convenient and easy to use device, easily allows examining patients with various pathologies and, therefore, offers a wide range of applications. To evaluate the scale and scope of implementing...
THE PHARMACOLOGICAL IMPORTANCE OF ANTIRRHINUM MAJUS- A REVIEW
ABSTRACT Antirrhinum majus (common snapdragon) is a species of flowering plant belonging to the genus Antirrhinum. It was used traditionally as a diuretic, for treatment of scurvy, liver disorders and tumors. The...
DESCRIPTIVE ANALYSIS OF THE FRESHWATER MALACOLOGICAL POPULATION, POTENTIAL VECTOR OF SCHISTOSOMIASIS, IN THE DAM LAKES OF OUERGHA WATERSHED (MOROCCO)
ABSTRACT The importance of the traditional knowledge of ethnic tribal people using plants for treatments of diseases has become very significant for future benefit of the human society. A field work was conducted...
DECOLOURIZATION OF REACTIVE DYES USING BACTERIA ISOLATED FROM TEXTILE DYE EFFLUENT
ABSTRACT The Bacillus licheniformis and Pseudomonas putida were isolated from Industrial effluent and was tested for decolorization activity against commercially important dyes such Reactive red 195, Reactive Yel...