EFFECT OF ETHANOLIC EXTRACT OF FLOWERS OF TECOMA STANS ON ACETIC ACID INDUCED COLITIS IN ALBINO RATS
Journal Title: Asian J of Pharm Sci & Tech - Year 2014, Vol 4, Issue 2
Abstract
ABSTRACT Aim to evaluate the effect of ethanolic extract of flowers of Tecoma stans on acetic acid induced colitis in albino rats. Ethanolic extract of Tecoma stans (EETS) was prepared by percolation method. Acute toxicity test was done by using Organization for Economic Cooperation and Development guidelines. Albino rats were divided into four groups of five animals each. Groups A and B received 3% gum acacia. Groups C and D received EETS 500 mg/kg body weight (BW) and 5- aminosalisylic acid 100 mg/kg BW respectively. Colitis was induced by transrectal administration of 4% acetic acid on 5 th day. All animals were sacrificed after 48 h of colitis induction and distal 10 cm of the colon was dissected. Colon was weighed for disease activity index (DAI) and scored macroscopically and microscopically. Biochemical assessment of tissue myeloperoxidase (MPO), catalase (CAT) and superoxide dismutase (SOD) was done in colonic tissue homogenate and malondialdehyde (MDA) was estimated in serum. T.stans showed significant (P < 0.05) reduction in DAI, macroscopic and microscopic lesion score as well as significant (P < 0.05) improvement in MPO, MDA, CAT, and SOD level as compared to Group B. The ethanolic extract of flowers of T.stans showed significant amelioration of experimentally induced colitis, which may be attributed to its antiinflammatory and antioxidant property. Key words: Antioxidant, Colitis, Tecoma stans.
Authors and Affiliations
S. Kameshwaran*, R. Senthil Kumar, S. Thenmozhi, M. Dhanalakshmi, K. Vasuki, K. Manjuladevi
Keywords
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