Effect of filgrastim (recombinant human granulocyte colony stimulating factor) on spatial memory in aged rats
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2015, Vol 5, Issue 5
Abstract
Background: Apart from functioning as a multimodal hematopoietic growth factor, granulocyte colony-stimulating factor (G-CSF) causes intense consequences on the brain. It has been viewed that G-CSF boosts the improvement from the neurologic deficits in rodent models of central nervous system diseases. Aims and Objective: To evaluate the efficacy of G-CSF as an intervention for improving cognitive deficits commonly associated with aging. Materials and Methods: In this study, male Wistar rats aged 21 months were treated for 2 weeks with G-CSF intraperitoneally at doses of 10, 50, and 70 mg/kg/day. The learning process was assessed by the reference memory task in the Morris water maze, by comparing the G-CSF–treated group with the control animals. All the rats received Morris water maze training (four trials/day for 5 days) in order to assess the hippocampal-dependent spatial learning and received a 60-s probe trial test of spatial memory retention 24 h after the twentieth trial. Result: Over 5 days of training, G-CSF (10, 50, and70 mg/kg/day) significantly reduced the latency and path length to finding the escape platform (P o 0.01). In probe trials (without platform), on the last day of training, the G-CSF–treated group spent significantly longer time in the platform quadrant when compared with the control animals (P o 0.01). Among the treated groups, the 50-mg/kg dosage of G-CSF induced the best rehearsals memory. Conclusion: The findings observed in this study support G-CSF as a promising therapeutic aid for cognitive enhancement in the aging phenomenon.
Authors and Affiliations
Hamid Sepehri, Elham Mehrazin
Keywords
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- EP ID EP107086
- DOI 10.5455/njppp.2015.5.1308201568
- Views 55
- Downloads 0
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