EFFECT OF ORAL CLONIDINE PREMEDICATION ON INTRAVENOUS ANAESTHETICS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 30
Abstract
[b] OBJECTIVES[/b]: To study the effect of oral clonidine premedication on the induction doses of intravenous thiopentone sodium and propofol. [b]METHODS[/b]: After ethical committee approval and informed consent, 120 ASA grade I and II patients were randomly allocated to four groups of 30 each. Group A received a placebo orally, 90 minutes before induction with thiopentone. Group B received clonidine 4µg/kg orally, 90 minutes before induction with thiopentone. Group C received a placebo orally, 90 minutes before induction with propofol. Group D received clonidine 4µg/kg orally, 90 minutes before induction with propofol. The patients were premedicated with Tab Diazepam 5 mg orally on the night before surgery. Inj. Glycopyrrolate 0.004 mg/kg IV was administered before starting anaesthesia. The patients were pre-oxygenated with 100% oxygen for 3 minutes and anaesthesia was induced with either thiopentone sodium 2.5% or propofol, slowly till loss of eyelash reflex was achieved. The dose of either thiopentone sodium or propofol required for induction of anaesthesia was noted. Inj. Succinylcholine 1.5 mg/kg was injected intravenously to facilitate tracheal intubation and after intubation anaesthesia was continued in the conventional manner. The heart rate and blood pressure were recorded throughout the procedure. [b]RESULTS:[/b] The dose of thiopentone sodium required for induction was significantly lower by 21.3% in the group B (3.65±0.3 mg/kg) as compared with the control group A (4.64±0.35 mg/kg), effect size, d=2.02, p<0.001. The dose of propofol required for induction was significantly lower by 16.01% in the group D (1.73±0.08 mg/kg) as compared with the control group C (2.06±0.06 mg/kg), effect size, d=0.92, p=0.001.[b] CONCLUSION[/b]: Oral clonidine premedication decreases the induction doses of both thiopentone sodium and propofol.
Authors and Affiliations
Pradeep M. S, Prabha P
Keywords
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- EP ID EP90173
- DOI 10.14260/jemds/1032
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