EFFECT OF PROLONGED ADMINISTRATION OF METHANOLIC EXTRACT OF GANODERMA LUCIDUM ON BLOOD GLUCOSE LEVEL IN NORMAL ALBINO RATS
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 2
Abstract
ABSTRACT The effect of methanolic extract of Ganoderma lucidum on blood glucose level was investigated in normal albino rats by enzymatic oxidation method. Doses of 200 mg/kg, 400 mg/kg and 800 mg/kg were administered to albino rats in groups A, B and C while rats in group D were used as control and administered with water. The extract was orally administered consecutively for 21 days, and two weeks withdrawal period was also monitored. Serum sample was collected from the experimental rats after sacrificing five rats weekly per each group. Pre-treatment, treatment and withdrawal values were analysed and compared to control. Blood glucose level was found to significantly (P<0.05) decrease within the treatment period compared to pre-treatment and control suggesting possible hypoglycemic effect of the methanolic extract of wild Ganoderma lucidum which may be used in the management of disease such as diabetes mellitus. Keywords: Ganoderma lucidum, Methanol extract, Blood glucose, Albino rats.
Authors and Affiliations
Shamaki BU, Ogbe AO, Abdulrahman FI, Sandabe UK
Keywords
Related Articles
- EP ID EP138710
- DOI -
- Views 126
- Downloads 0
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF OLANZAPINE AND FLUOXETINE IN TABLET DOSAGE FORM
ABSTRACT A new precise, accurate, reliable validated method for the determination of Olanzapine and Fluoxetine has been developed by using reverse phase high performance liquid chromatography (RP-HPLC) in pharma...
AN OVERVIEW ON HPLC, UPLC AND ITS TROUBLESHOOTING
ABSTRACT HPLC and UPLC Systems take advantage of technological strides made in particle chemistry performance, system optimization, detector design, and data processing and control. When taken together, these ach...
MICELLAR ELECTROKINETIC CHROMATOGRAPHY: AN OVERVIEW
ABSTRACT Micellar electrokinetic chromatography (MEKC) is a useful branch of capillary electrophoresis (CE) that utilizes surfactant above critical micellar concentration (CMC) as pseudo-stationary phase. MEKC c...
THREE SIMPLE VALIDATED UV SPECTROPHOTOMETRIC METHODS FOR THE SIMULTANEOUS ESTIMATION OF TIMOLOL MALEATE AND BRIMONIDINE TARTRATE AND THEIR COMPARISON USING ANOVA
ABSTRACT Timolol Maleate and Brimonidine Tartrate combination is used for the topical treatment of intra-occular pressure in patients of glaucoma. Three rapid, simple, accurate and precise UV spectrophotometric met...
METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC ANALYSIS OF BROMFENAC IN RABBIT PLASMA
ABSTRACT A simple, precise, rapid, and accurate reverse phase high performance liquid chromatography method was developed for the estimation of Bromfenac in Rabbit plasma by using Paracetamol as IS. The protein p...