Effect of Sitagliptin in Combination with Glimepiride on Glycemic Control and Islet Cell Diameter/Proliferation in A Model of Type 2 Diabetic Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 9
Abstract
The aim of the present study was to investigate the effect of monotherapy with sitagliptin, or its combination with glimepiride in glycemic control, islet cell diameter and its proliferation in type 2 diabetic rats. Rats were fed with a high fat diet followed by injection with a low dose of streptozotocin to induce type 2 diabetes. Then, rats were switched to normal diet and for other 28 days. Monotherapy with sitagliptin did not affect the body weight, while its combination with glimepiride did not induce a significant change. The combination increased the % change in body weight compared to sitagliptin alone. All the treatment regiment enhanced glucose clearance as indicated by a reduction in the area under the curve. Pancreatic immunohistochemistry and morphometric analysis were performed to measure the diameter of islet cells, insulin-positive area and the number of Ki-67 positive nuclei. In sitagliptin group, diameter of large-sized islets was 2-fold greater than those observed in diabetic group. The monotherapy with glimepiride did not change the islet-cell diameter. Further, the combination group showed better glycemic control and greater cell proliferation compared to monotherapies. Consequently, we conclude that the combination therapy of sitagliptin/glimepiride has synergistic effect.
Authors and Affiliations
Noha A. Mohamed , Sawsan A. Zaitone , Yasser M. Moustafa
Keywords
Related Articles
- EP ID EP87894
- DOI -
- Views 146
- Downloads 0
The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq
Abstract:- Eucalyptus species grown in Iraq were included Eucalyptus bicolor (Syn: Eucalyptus largiflorens), Eucalyptus griffithsii, Eucalyptus camaldulensis (Syn: Eucalyptus rostrata) Eucalyptus incrassate, Eucalyptus t...
Effect of Nonsteriodal Anti-Inflammatory Drugs on Orthodontic Tooth Movement – Review
Orthodontic tooth movement is a biological response towards mechanical force resulting in remodeling of the periodontal structure allowing for tooth movement. Periodontal remodelling is a complex process regu...
Effect of Probiotic Lactobacillus plantarum (NCDC LP20) on Enhanced Innate Immunological Indices of Freshwater Fish.
In according to several reports, the advantageous effects of bacteria on fish have well been documented. Probiotics as an alternative strategy have been suggested to be used as reinstatement for antimicrobial drugs and g...
[b] A STUDY OF MORBIDITY PROFILE OF GERIATRIC POPULATION IN THE FIELD PRACTICE AREA OF RURAL HEALTH TRAINING CENTRE, PAITHAN OF GOVT. MEDICAL[/b] [b]COLLEGE, AURANGABAD[/b]
Hepatoprotective effects of simvastatin on paracetamol -induced hepatic damage in rats
ABSTRACT: This study was designed to investigate the possibility of statins hepatoprotection in paracetamol toxicicity. Paracetamol hepatotoxicity was associated with significant decrease in the serum total&nb...