Effect study of sex hormone in the multiple sclerosis of common neurological disorders
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 4
Abstract
Multiple sclerosis (MS) is one of most common neurological disorders, mainly affecting women. The central nervous system (CNS) of this autoimmune disease is characterized by intermittent or chronic damage to the myelin sheaths (demyelination), local inflammation and axonal degeneration. During the early relapsing/remitting stages of MS, myelin can regenerate. However, as the disease progresses, both amount and activity of regenerated axons becomes insufficient, leading to impaired axon conduction, neurodegeneration and the worsening symptoms. Epidemiological study found that distinct symptom alleviation of diseases at a certain periods would be shown in women during pregnancy. The following basic researches indicated that sex hormones especially progesterone can significantly reduce the disease severity, moreover, the protective effect of sex hormone on the nervous system has become the research focus.
Authors and Affiliations
Yanyan Xin , Dayong Xu , Xiaoqing Yang , Aizhen Liu , Xinhua Zhou , Baozhi Guo
Keywords
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