Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2013, Vol 26, Issue 5
Abstract
This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester (L-NAME). Rats are given L-NAME for 15 days and the propolis for the last 5 days with L-NAME together. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyltransferase in the L-NAME group compared to control group have increased (P<0.05). The levels of these parameters in L-NAME+propolis group compared to the L-NAME group have decreased (P<0.05). L-NAME caused increase (P<0.05) in levels of glucose, albumin, globulin, creatinine, urea, triglyceride and cholesterol. Erythrocyte number, total leukocyte, hemoglobin, hematocrit, neutrophil and monocyte decreased (P<0.05), platelets and lymphocyte increased (P<0.05) in L-NAME+propolis group compared to the L-NAME group. The study concluded that homeostasis is modulated in L-NAME administrated rats by adding propolis which causes increasing generation of vascular nitric oxide.
Authors and Affiliations
Zeliha Talas, Ayse Gogebakan, Ibrahim Orun
Keywords
Related Articles
- EP ID EP161975
- DOI -
- Views 54
- Downloads 0
An investigation of the anti-diabetic effects of an extract from Cladonia humilis
The effect of Cladonia humilis on glycaemic metabolism was researched in this studied. The blood glucose, insulin secretion and glycogen synthesis of the hyperglycemic mice induced by alloxan were analyzed respectively....
Green approach towards the determination of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms
A simple eco-friendly method has been developed for detection of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms. Both conventional system and microwave assisted procedures are used for the deve...
Analysis of EPA and DHA in the viscera of marine fish using gas chromatography
The viscera of 10 kinds of marine fishes were collected for fish oil extraction and detection of DHA and EPA, two most important polyunsaturated fatty acids. The fish oil extraction ratio for the evaluated fishes v...
Unpredictable chronic mild stress induced behavioral deficits: A comparative study in male and female rats
Stress is an important precipitant factor for depression. Changes in various body systems that occur in depression are similar to those observed in response to stress. Chronic stress may alter behavioral, neurochem...
Formulation and evaluation of a single vial lyophilized preparation of technetium-99m labeled ethylene dicysteine as a renal scintigraphic agent
99mTc labeled N-N-ethylene-L, L-dicysteine (EC) was introduced in form of multiple-step kit as an alternate renal imaging radiopharmaceutical for commonly used 99mTc-MAG3. We developed a single component lyophilize...