EFFICIENCY OF TOPICAL PHENYTOIN ON HEALING IN DIABETIC ULCER: A RANDOMIZED CONTROL TRIAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 23
Abstract
Diabetic foot ulcers are the major complication of diabetes mellitus; 15% of diabetic people suffer from foot ulcers. Phenytoin is used as a topical application in many studies on diabetic foot ulcers and it is found to stimulate the formation of granulation tissue as early as 2-7 days. 1 OBJECTIVE The objective of this study was to compare the efficiency of topical phenytoin application on healing in diabetic foot ulcer with control group using conventional wound dressing. METHOD Totally, 100 patients with diabetic foot ulcer attending Thanjavur Government Medical College Hospital are randomized into two groups, assigned regular saline and betadine dressing for the control group. 2 and phenytoin powder application for the study group. Patient with vascular impairment or uncontrolled diabetes are not included. Both study and control group are compared in terms of number of days required for healing, rate of granulations tissue formation. Rate of reduction in mean ulcer surface area. Quality of graft bed. Skin graft take up and serial culture and sensitivity of wound swabs to assess the effect of topical phenytoin on bacterial load. RESULTS The rate of granulation tissue formation was assessed at the end of 2 weeks; 81 to 90% granulation was seen in study group. In study group, 84% cases graft take up was good and 70% in the control group. Graft take up was 72.4% and 58.43% respectively. Hospital stay 21 days in study group and 45 days in control group. CONCLUSION In our present study it was concluded that the rate of granulation tissue formation, overall graft survival and patient compliance was better in topical phenytoin dressing group. 3 as compared to conventional dressing group. 4
Authors and Affiliations
Jayaraman , Solaiappan
Keywords
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- EP ID EP123310
- DOI 10.14260/jemds/2016/286
- Views 93
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