Estrogen-sensitive hereditary angioedema type II: a case report and review
Journal Title: International Journal of Medical Science and Public Health - Year 2016, Vol 5, Issue 3
Abstract
Hereditary angioedema (HAE) is a rare autosomal condition due to inherited deficiency of C1 esterase inhibitor (C1INH). Estrogen reduces the concentration of C1INH and trigger angioedema; however, the estrogen sensitivity pattern is variable in HAE. Proper diagnosis and management is essential as this condition sometimes becoming life-threatening due to potential airway obstruction. We reported a 27-year-old woman experienced recurrent episodes of lips and face swellings over the last 4 years. Patient has positive family history of similar recurrent angioedema in her brother and cousin. Laboratory findings revealed normal C3, C4, C1q, and C1INH quantity but low activity (36% decreased). Subsequent visits revealed the intake of oral contraceptive pills and improvement of symptoms after discontinuation. To our knowledge, this is the first case report of HAE type II with estrogen-sensitive pattern in a Saudi woman improved after cessation of oral contraceptive pills.
Authors and Affiliations
Majdy M Qutub
Keywords
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- EP ID EP164473
- DOI 10.5455/ijmsph.2016.18112015208
- Views 82
- Downloads 0
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