Evaluation of cytotoxicity and antiviral activity of ivermectin against Newcastle disease virus
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
Cytotoxic and antiviral potential of ivermectin and ribavirin was evaluated. Cytotoxicity was checked on chick primary fibroblast cell line through MTT assay. Antiviral potential was determined against Newcastle disease virus on 9-day old chicken embryos. Six different concentrations (200, 100, 50, 25, 12.5 and 6.25µg/mL) of both the drugs were evaluated. The 100µg/mL concentration of ivermectin and higher were cytotoxic. The 25µg/mL concentration of ribavirin and higher were cytotoxic. Comparison of ivermectin and ribavirin showed that ivermectin was safe at 50µg/mL and lower concentrations. Ribavirin was protective for cell at 12.5µg/mL and 6.25µg/mL only. Comparison of antiviral activity indicated that ivermectin has strong antiviral potential at 100µg/mL and higher but same concentrations were cytotoxic. Ribavirin showed strong antiviral potential at all concentrations.
Authors and Affiliations
Sidra Azeem , Muhammad Ashraf , Muhammad Adil Rasheed , Aftab Ahmad Anjum , Rabia Hameed
Keywords
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