Evaluation of folate and vitamin B12 levels in lead exposed workers
Journal Title: Dicle Tıp Dergisi - Year 2015, Vol 42, Issue 3
Abstract
Objective: Lead (Pb) is a heavy metal and causes dysfunction in hematopoietic, cardiovascular, renal and hepatic systems. The aim of this study is to evaluate the effect of lead exposure on serum vitamin B12 and folate levels. Methods: 944 patients who were referred to Ankara Occupational Disease Hospital between 2010 and 2014 for periodic examination and whose whole blood lead, serum vitamin B12 and folate levels were assessed are included in this study. 432 patients with whole blood lead levels over 10 μg/dL are defined as exposed group and 512 patients with lead levels below 10μg/dL are considered as control group. Vitamin B12 and folate levels were compared between two groups. Correlation analysis was also performed. Results: In the lead exposed group the median folate level was 6.3 ng/mL (3.60-17.46) and median vitamin B12 level was 310 pg/mL (180-854) where as folate level was 6.8 (3.60-19.67) ng/mL and median vitamin B12 level was 324 pg/mL (190-833) in the control group. The difference between two groups was statistically significant (p value: <0.001 for folate and 0.015 for vitamin B12). Lead levels correlated negatively with folate levels (r=-0.105; p=0.001). There was no correlation between lead and vitamin B12 (r=-0.061, p=0.062). Conclusion: This study demonstrated that serum folate and vitamin B12 concentrations were negatively associated with lead exposure. It may be important to keep sufficient levels of these micronutrients to prevent possible harmful effects of Pb exposure regarding hyperhomocysteinemia. Key words: Lead exposure, vitamin B12, folate
Authors and Affiliations
Murat Büyükşekerci, Ceylan Bal, Mehmet Alagüney, Erol Ağış, Meşide Gündüzöz, Asım Hocaoğlu, Lütfiye Tutkun, Ömer Yılmaz
Keywords
Related Articles
- EP ID EP132969
- DOI 10.5798/diclemedj.0921.2015.03.0577
- Views 85
- Downloads 0
Diabetik maküler ödemde subtenon triamsinolon ile kombine fokal lazer fotokoagülasyonun etkinliğinin değerlendirilmesi
Amaç: Bu çalışmanın amacı subtenon triamsinolon (ST) enjeksiyonu ile fokal lazer fotokoagülasyon kombinasyonunun diyabetik maküler ödem (DMÖ)’de etkinlik ve güvenilirliğinin araştırılmasıdır. Gereç ve yöntem: Diyabet...
An epidemiologic study on urothelial carcinomas of bladder
In this study, the epidemiological analysis of the bladder cancers was performed accompanied by the known environmental factors. Materials and methods: In this retrospective study, pathology archival materials of 420 pa...
A rare cause of acromegaly: McCune-Albright syndrome
McCune-Albright syndrome is characterized by polyostatic fibrous dysplasia, brown spots on the skin (café au lait pigmentation) and autonomous endocrine hyperfunction. Early puberty and other endocrinological manifestati...
Rare presentation of postcholecystectomy syndrome: Magnetic resonance cholangiopancreatography findings of remnant gallbladder
Post-cholecystectomy syndrome is defined as recurrent or persistent symptoms, consisting of upper abdominal pain or dyspepsia after cholecystectomy. Post-cholecystectomy syndrome occurs due to biliary and non-biliary dis...
Sexual dysfunction in a patient with rheumatoid arthritis treated with adalimumab
Rheumatoid arthritis (RA) is a chronic, systemic and inflammatory disease characterized by symmetric polyarthritis and arthralgia, morning stiffness, fatigue and rheumatoid nodules. Multifactorial etiology such as geneti...