Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice
Journal Title: Journal of BioScience and Biotechnology - Year 2014, Vol 3, Issue 2
Abstract
The Jamaican bitter yam (Dioscorea polygonoides) (ITIS) is known to possess potent antidiabetic and hypocholesterolemic properties and can therefore be exploited for associated nutraceutical/pharmaceutical purposes. It however possesses bioactive compounds known to promote organ damage when ingested in excess. This study investigates the effects of bitter yam consumption at a concentration of 5% on liver and kidney damage/function parameters. Normocholesterolemic mice fed bitter yam supplemented diets experienced significant increases in serum aspartate aminotransferase activity and bilirubin, magnesium and phosphorus concentrations. Significant increases were also observed in serum aspartate aminotransferase activity and blood urea nitrogen concentration of the genetically modified hypercholesterolemic mice fed supplemented diets. These results suggest mild kidney damage in both mice species and a significant increase in the rate of erythrocyte haemolysis in the normocholesterolemic mice.
Authors and Affiliations
Dewayne Stennett, Frederick Oladeinde, Andrew Wheatley, Lowell Dilworth, Christine Hohmann , Joseph Bryant, Helen Asemota
Molecular cloning, expression and in vitro analysis of soluble cationic synthetic antimicrobial peptide from salt-inducible E. coliGJ1158
Antimicrobial peptides are the upcoming therapeutic molecules as alternative drugs to the existing antibiotics owing to their potent action against pathogenic microorganisms. In this study, to obtain an antimicrobial pep...
Optimization of Neutral Comet Assay for studying DNA double-strand breaks in pea and wheat
This study describes an adaptation of the Comet assay under neutral conditions for mono- and dicotyledonous plants pea (Pisum sativum L.) and wheat (Triticum aestivum L.). Modifications concern lysis and electrophoresis...
Evaluation of the phenotypic variation in a caper (Capparis spinosa L.) population growing in south of Tehran using multivariate analysis
The aim of this study was to investigate the phenotypic variation among 100 caper ([i]Capparis spinose [/i]L.) plants growing naturally in south of Tehran. Plant samples were taken randomly from three different regions o...
Biosynthesis of highly unsaturated fatty acids by hydrocarbon degrading microorganisms
Disruption of polyunsaturated fatty acids (PUFA) metabolism leads to many diseases. In this study, producers of γ-linolenic acid (GLA), arachidonic acid (ARA) and eicosapentaenoic acid (EPA) were selected: Cephalos...
Optimized production of extracellular proteases by [i]Bacillus subtilis[/i] from degraded abattoir waste
Proteases are ubiquitous in occurrence and are found in all living organisms. These are essential for cell growth and differentiation. The extracellular proteases are of a high commercial value and find multiple applicat...