Formulation and evaluation of gastroretentive controlled release tablets of alfuzosin hydrochloride
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 6
Abstract
Alfuzosin hydrochloride is a novel drug used in the treatment of urinary incontinency. The purpose of this research was to develop controlled release floating matrix formulations of Alfuzosin HCl. Floating matrix tablets of Alfuzosin HCl were prepared using hydroxypropyl methylcellulose (HPMC), Polyethylene oxide (PEO), Carbopol 971P NF polymer (Direct compressible) and Blend of Polyvinyl Acetate and Povidone 30 (80:19:1(0.8% sodium laury sulfate and 0.2% silica)). Combination of citric acid and sodium bicarbonate were also used as gas forming agent. Matrix formulations were prepared by direct compression method and evaluated for floating, in vitro drug release profile and swelling characteristics. The mechanism of drug release was found to follow non-Fickian or anomalous type. The data obtained from the invitro release studies demonstrated that the floating matrix tablets containing HPMC 100K CR (controlled-release) and carbopol along with sodium CMC were found to sustain the release of drug over a period of 12 hours. Formulations containing 25% PEO 303WSR was also capable of sustaining delivery the release of Alfuzosin HCl.
Authors and Affiliations
Nijaguni Revansiddayya Rudraswamy Math , Vankdari Rama Mohan Gupta
Keywords
Related Articles
- EP ID EP117530
- DOI -
- Views 163
- Downloads 0
Hypoglycemic effects of three Iranian edible plants; jujube, barberry and saffron: Correlation with serum adiponectin level
One of the most common disorders of the endocrine system is diabetes mellitus. This disease is associated with dyslipidemia. Adiponectin is a protein hormone that secreted by adipocytes and has an important role in...
Clinical observation of 32 cases with transplantation of autologous bone marrow stem cells on diabetes and its complications
By observing the curative effect of autologous stem cells changes before and after the treatment, to explore the stem cell treatment of diabetes and its complications. 32 patients were type 2 diabetic patients with...
Antioxidant studies on monosubstitutedchalcone derivatives - understanding substituent effects
An overproduction of reactive oxygen species beyond basal levels generated continuously in the body as part of natural metabolic processes often results in serious and diverse disease conditions including cancer. C...
Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity
The onset of 21st century witnessed the awareness among the masses regarding the diet-health linkages. The researchers attempted to explore traditional products/plants were in the domain of pharmacy and nutrition f...
Latex agglutination: Diagnose the early cryptococcus neoformans test of capsular polysaccharide antigen
This paper aims to discuss the early diagnosis value of latex agglutination test in Cryptococcal meningitis. The cerebrospinal fluid (CSF) of 112 patients with definite Cryptococcal meningitis and 26 patients with...