FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF DILTIAZEM
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 4
Abstract
ABSTRACT Diltiazem is a beta- or calcium channel- blockers .It binds to a site on the extracellular aspect of the α-subunit of the Na+ /K+ ATPase pump in the membranes of heart cells (myocytes) and decreases its function). The aim is to formulate various trail batch of immediate release tablet of Diltiazem two different dosage (0.25mg &0.125mg) using corn starch as Superdisintegrant in different trail batches by wet granulation method. The drug-excipients interaction was investigated by UVspectrophotometer. The tablets of Diltiazem were evaluated for various pre and post compression parameters like angle of repose, compressibility index, hausner’s ratio, tablet hardness, friability and in vitro disintegration and dissolution. Their results were found satisfactory and suggest that maximum in vitro dissolution profile of fourth approach formula were satisfactory and all the results for pre and post compression parameters found to be very near to innovator drug data. Key words: Diltiazem, Immediate release tablet, Superdisintegrants, Corn starch.
Authors and Affiliations
Remya PN*, Damodharan N, Kavitha R, Saraswathi TS, Murugan M
Keywords
Related Articles
- EP ID EP112571
- DOI -
- Views 194
- Downloads 0
DESCRIPTIVE ANALYSIS OF THE FRESHWATER MALACOLOGICAL POPULATION, POTENTIAL VECTOR OF SCHISTOSOMIASIS, IN THE DAM LAKES OF OUERGHA WATERSHED (MOROCCO)
ABSTRACT The importance of the traditional knowledge of ethnic tribal people using plants for treatments of diseases has become very significant for future benefit of the human society. A field work was conducted...
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF SOME d10 METAL COMPLEXES WITH A NEW MANNICH BASE N-[(DIPHENYLAMINO) METHYL] ACETAMIDE
ABSTRACT The complexes of ZnII, CdII and HgII with N-[(Diphenylamino)methyl]acetamide (DPAMAce) have been synthesized and characterized. The resulting complexes were characterized by elemental analysis, conductiv...
PRELIMINARY PHYTOCHEMICAL INVESTIGATION AND TLC ANALYSIS OF PEEL AND SEED EXTRACTS OF PERSEA AMERICANA
ABSTRACT Medicinal plants are as “old as mankind on earth” which are used in herbal medicine to treat diseases. Excellent research works and reviews have documented a list of medicinal plants used in every part o...
THE INFLUENCE OF pH ON DRUG RELEASE FROM ZIDOVUDINE MATRICES CONTAINING DIFFERENT GRADES OF HYDROXYPROPYL METHYL CELLULOSE
ABSTRACT The present study examines the effect of multimedia dissolution profile on the drug release of sustained release hydrophilic matrices of zidovudine containing combination of different grades of hydroxypr...
DECOLOURIZATION OF REACTIVE DYES USING BACTERIA ISOLATED FROM TEXTILE DYE EFFLUENT
ABSTRACT The Bacillus licheniformis and Pseudomonas putida were isolated from Industrial effluent and was tested for decolorization activity against commercially important dyes such Reactive red 195, Reactive Yel...