Glucose-6-Phosphate Dehydrogenase Deficiency among Male Blood Donors inSana’a City, Yemen
Journal Title: Oman Medical Journal - Year 2012, Vol 27, Issue 1
Abstract
Objectives: To determine the prevalence of Glucose-6-phosphatedehydrogenase (G-6-PD) deficiency among Yemeni people fromdifferent regions of the country living in the capital city, Sana’a,giving an indication of its overall prevalence in Yemen. Methods: A cross-sectional study was conducted among Yemenimale blood donors attending the Department of Blood Bank atthe National Centre of the Public Health Laboratories in thecapital city, Sana’a, Yemen. Fluorescent spot method was used forscreening, spectrophotometeric estimation of G-6-PD activityand separation by electrophoresis was done to determine the G-6-PD phenotype. Results: Of the total 508 male blood donors recruited into thestudy, 36 were G-6-PD deficient, giving a likely G-6-PD deficiencyprevalence of 7.1%. None of these deficient donors had history ofanemia or jaundice. Thirty-five of these deficient cases (97.2%)showed severe G-6-PD deficiency class II (<10% of normalactivity), and their phenotyping presumptively revealed a G-6-PDMediterraneanvariant. Conclusion: The results showed a significant presence of G-6-PD deficiency with predominance of a severe G-6-PD deficiencytype in these blood donors in Sana’a City, which could representan important health problem through occurrence of hemolyticanemia under oxidative stress. A larger sample size is needed todetermine the overall prevalence of G-6-PD deficiency, and shouldbe extended to include DNA analysis to identify its variants in Yemen.
Authors and Affiliations
Hafiz Al-Nood, Fakiha Bazara, Rashad Al-Absi, Molham AL-Habori
Keywords
Related Articles
- EP ID EP86472
- DOI 10.5001/omj.2012.09
- Views 75
- Downloads 0
Diabesity in the Arabian Gulf: Challenges and Opportunities
Diabesity (diabetes associated with obesity) is a major global and local public health concern, which has almost reached an epidemic order of magnitude in the countries of the Arabian Gulf and worldwide. We sought to rev...
Neck Circumference as a Useful Marker for Screening Overweight and Obesity in Children and Adolescents
Objectives: Overweight and obesity at an early age are an important criterion for predicting chronic diseases. Each anthropometric method available to assess obesity has its limitations. Recently, one of the indices prop...
Hypocalcemia Associated with Subcutaneous Fat Necrosis of the Newborn: Case Report and Literature Review
Subcutaneous fat necrosis of the newborn (SCFNN) is a rare benign inflammatory disorder of the adipose tissue but may be complicated by hypercalcemia or less frequently, hypocalcemia, resulting in morbidity and mortality...
Successful Revascularization of Near Total Amputation of the Upper Limb at the Sultan Qaboos Hospital, Salalah
Severe crush injuries to the upper limb may require a formal amputation with devastating consequences to the patient. We report a patient with a near total amputation at the level of mid-forearm who underwent revasculari...
Primary Health Care in Oman: Shaping the Future
The success of any health care system in any part of the world depends entirely on the strength and reliability of its primary health care (PHC) system. It is the first portal of entry for patients to the health care sys...