Hepatoprotective Role of Sodium Selenite Against Oxidative Damage Induced by Mercuric Chloride in Rat Albinos Wistar
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2013, Vol 9, Issue 4
Abstract
[b]Background:[/b] The present study was undertaken, to evaluate the protective effect of sodium selenite against mercuric chloride induced oxidative stress in experimental rats. Female Albinos Wistar rats randomly divided into four groups, were the first was served as a control, whereas the remaining groups respectively treated with: sodium selenite (1mg/ kg b.w; ip), mercuric chloride (1 mg/kg body weight i.p) and combination of sodium selenite and HgCl[sub]2[/sub]. Change in liver enzyme activities, thiobarbituric acid reactive substances (TBARS) level, antioxidants and reduced glutathione (GSH) contents were determined after 10 days experimental period. [b]Results:[/b] Exposure of rats to mercuric chloride caused a significant increase the lipid peroxidation level along with corresponding decrease in the reduced glutathione and various antioxidant enzymes in liver. And increase in serum: glucose level, APL and transaminases activities and decreased in total protein and albumin levels. Furthermore, treatment with mercuric chloride caused a marked elevation of liver weight and decreased body weight. Supplementation of sodium selenite resulted in decreased of lipid peroxidation level and in the serum: AST, ALT and APL activities were decreased along with increase in total protein, albumin and liver GSH levels. The activities of antioxidants enzymes: glutathione peroxidase (GSH -Px) and glutathione –S-transferase (GST) were also concomitantly restored to near normal level by sodium selenite supplementation to mercuric chloride intoxicated rats. Liver histological studies have confirmed the changes observed in biochemical parameters and proved the beneficial role of sodium selenite. [b]Conclusion:[/b] The results clearly demonstrate that sodium selenite treatment augments the antioxidants defense mechanism in mercuric chloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases.
Authors and Affiliations
Youcef Necib, Ahlem Bahi, Sakina Zerizer, Cherif Abdennour, Mohamed Boulakoud
Keywords
Related Articles
- EP ID EP162188
- DOI -
- Views 94
- Downloads 0
Mathematical modeling of heat transfer between the plant seedling and the environment during a radiation frost
The power of the internal heat source sufficient to maintain a positive temperature of plants during one of the possible form of cold stress - radiation frost was determined with the help of numerical simulation. The si...
Growth and Nitrogen Fixation in Silicon and/or Potassium Fed Chickpeas Grown under Drought and Well Watered Conditions
A pot experiment was conducted to study the effects of silicon (Si) and/or potassium (K) on plant growth, nitrogen uptake and N2-fixation in water stressed (FC1) and well watered (FC2) chickpea plants using [sup]15[/sup]...
Dehydration stress associated variations in rectal temperature, pulse and respiration rate of Marwari sheep
The present investigation was carried out in adult female Marwari sheep to evaluate the dehydration stress associated variations in rectal temperature, pulse and respiration rate. The whole experiment was divided into co...
Oxidative Stress Induced Lipid Peroxidation And DNA Adduct Formation In The Pathogenesis Of Multiple Myeloma And Lymphoma
[b]Objective:[/b] To access the oxidative stress status by quantification of byproducts generated during lipid peroxidation and DNA breakdown products generated during DNA damage in the blood serum of multiple myeloma an...
The influence of high Cd2+ concentrations on lipid peroxidation and antioxidant system function of wheat (Triticum aestivum) and rye (Secale cereale) etiolated shoots
The influence of high Cd[sup]2+[/sup] concentrations on lipid peroxidation and antioxidant system function of winter wheat ([i]Triticum aestivum[/i]) and rye ([i]Secale cereale[/i]) etiolated shoots. It is shown that eti...