High-fat diet is associated with endotoxemia and low-grade inflammation
Journal Title: Nepal Journal of Medical Sciences - Year 2012, Vol 1, Issue 2
Abstract
Endotoxin (lipopolysaccharide [LPS]) is located at the outer membrane of the Gram-negative bacteria such as Escherichia coli, Salmonella, Shigella, Pseudomonas, Neisseria, Haemophilus influenzae, Bordetella pertussis and Vibrio cholerae, and is regarded as one of the potent virulence factors of these bacterial species. In the circulation system, 80–97% of it is bound to the lipoproteins. The subclinical elevation in circulating endotoxin level is known as the metabolic endotoxemia. This elevation is not overtly apparent in a clinical setting but is being investigated as a significant potential etiology for several chronic diseases. The effect of high doses of LPS (10-200 ng/ml) on inflammation is well known, but the research is still going on about the effect of very low doses of LPS (1-100 pg/ml) on inflammatory and metabolic alterations.
Authors and Affiliations
Umid Shrestha
Keywords
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- EP ID EP103483
- DOI http://dx.doi.org/10.3126/njms.v1i2.6600
- Views 141
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