High-fat diet is associated with endotoxemia and low-grade inflammation
Journal Title: Nepal Journal of Medical Sciences - Year 2012, Vol 1, Issue 2
Abstract
Endotoxin (lipopolysaccharide [LPS]) is located at the outer membrane of the Gram-negative bacteria such as Escherichia coli, Salmonella, Shigella, Pseudomonas, Neisseria, Haemophilus influenzae, Bordetella pertussis and Vibrio cholerae, and is regarded as one of the potent virulence factors of these bacterial species. In the circulation system, 80–97% of it is bound to the lipoproteins. The subclinical elevation in circulating endotoxin level is known as the metabolic endotoxemia. This elevation is not overtly apparent in a clinical setting but is being investigated as a significant potential etiology for several chronic diseases. The effect of high doses of LPS (10-200 ng/ml) on inflammation is well known, but the research is still going on about the effect of very low doses of LPS (1-100 pg/ml) on inflammatory and metabolic alterations.
Authors and Affiliations
Umid Shrestha
Keywords
Related Articles
- EP ID EP103483
- DOI http://dx.doi.org/10.3126/njms.v1i2.6600
- Views 145
- Downloads 0
A study on Complications of ventriculoperitoneal shunt surgery in Bir Hospital, Kathmandu, Nepal
Background: Ventriculoperitoneal shunt is one of the most commonly performed neurosurgical procedure, both on the elective and emergency basis. However this procedure is dreaded because of complications. There is l...
Role of serum bilirubin as a marker of acute gangrenous appendicitis
Background: This study has compared the difference in serum bilirubin between patients with gangrenous and non-gangrenous appendicitis. Methods: A prospective analytical study of, 141 patients who underwent append...
Old and New Players in Oral Antiplatelet Therapy in Treatment of Acute Coronary Syndrome
Oral antiplatelet therapy plays an important role in treating patients with acute coronary syndrome (ACS), including patients with unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI) and p...
Gonococcal infections: The trends of antimicrobial susceptibility of Neisseria gonorrhoeae in Western Nepal
Background: Gonorrhea is caused by Neisseria gonorrhoeae, is an important public health problem and is the second most common reportable sexually transmitted bacterial infection. Present study was conducted to dete...
Etiology and clinical profile of inpatients with Community acquired pneumonia in Manipal Teaching hospital, Pokhara, Nepal
Background: Community acquired pneumonia (CAP) is major cause of morbidity in adults. The presentation may be varied. Severity of the disease is seen to be more if co-morbid conditions are present, especially chronic lun...