HUMAN AMNIOTIC MEMBRANE GRAFTING: A BOON IN OCULAR CHEMICAL INJURIES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 12
Abstract
Amniotic membrane is the innermost layer of the fetal membranes. It has a stromal matrix, a collagen layer, and an overlying basement membrane with a single layer of epithelium. (1) Amniotic membrane has unique properties including anti-adhesive effects, bacterio-static properties, wound protection, pain reduction, and epithelialisation effects. Another characteristic of amniotic membrane is the lack of imunogenicity. (2) Amniotic membranes have been used as a dressing to promote healing of chronic ulcers of the leg and as a biological dressing for burned skin and skin wounds. (3, 4) It has also been used in surgical reconstruction of artificial vagina, for repairing omphaloceles, and to prevent tissue adhesion in surgeries of the abdomen, head, or pelvis. (5, 6) Amniotic membrane has been successfully used in ocular conditions like persistent epithelial defects (7), pterygium, (8) Symblepharon (9) and for ocular surface reconstruction.(10, 11) The purpose of this study was to evaluate the use of cryopreserved Human amniotic membrane graft( HAMT), with or without limbal autograft transplantation (LAT) in patients with previous and fresh chemical eye injuries respectively. Institutional ethical committee approval was obtained.
Authors and Affiliations
Shashikala P, Mangalagowri
Keywords
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