Hypo and hyperglycemia among tramadol overdose patients in Loghman Hakim Hospital, Tehran, Iran
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 6
Abstract
Tramadol is a synthetic and centrally active analgesic. Hypoglycemia as another possible major side effect among abusers has not been known well. Our objective is evaluation of the Blood Glucose Level (BGL) among tramadol-overdosed patients. This prospective cross-sectional study was performed from Feb to June 2013; BGL was measured at the time of admission, 8 and 12 hours later. All patients with hypoglycemia received infusion of 0.5-1gr/kg of hypertonic dextrose and their BGL was checked every hour until normal BGL. Patients’ demographic, clinical and paraclinical data were collected. Totally, 128 patients with a mean (SD) age of 24.5 (6.9) years were recruited; 127 (99.2%) were male. Seizure occurred in 59.4% cases. Mean ±SD admission BGL was 94.88±21.5mg/dL. Fourteen patients experienced hypoglycemia within 12 hours period. Hyperglycemia was experienced in 8 patients (6.25%) on admission day. There was no significant relation between the dose of tramadol and BGL. In conclusion, hypoglycemia must be considered asan important side effect of tramadol-overdose. It is suggested that serial BGL monitoring in cases of Tramadol-overdose should be done for early recognition of hypoglycemia and its timely management. Also hyperglycemia may be revealed.
Authors and Affiliations
Soheil Nasouhi , Parmis Razi , Haleh Talaie , Abdolkarim Pajoumand , Sevil Aghapour , Mitra Rahimi , Ahmad Ghochani Khorasani , Mohammad Mashayekhian , Abbas Aghabiklooei
Keywords
Related Articles
- EP ID EP133138
- DOI -
- Views 92
- Downloads 0
Antineoplastic activity of Holoptelea integrifolia (Roxb.) Planch bark extracts (in vitro)
Cancer remains the major public health concern with a number of cancer patients relying on chemotherapy as a treatment option. Although, advances in biomedical research have led to increased anticancer agents in re...
Quality evaluation of Houttuynia cordata Thunb. by high performance liquid chromatography with photodiode-array detection (HPLC-DAD)
Abstract: A new, validated method, developed for the simultaneous determination of 16 phenolics (chlorogenic acid, scopoletin, vitexin, rutin, afzelin, isoquercitrin, narirutin, kaempferitrin, quercitrin, quercetin...
Hepatoprotective and toxicological studies of Salvia bucharica methanolic extract in rabbits
Most of the species of genus Salvia are famous for having medicinal properties due to their chemical constituents. Salvia bucharica (Lamiacea) is found in Balochistan near Quetta in Hannaurak and Kalat. It is used...
Antioxidant activity of simvastatin prevents ifosfamide-induced nephrotoxicity
Ifosfamide is an anticancer agent used largely in treatment of solid tumors. The mainstay dose-limiting toxicity of ifosfamide is nephrotoxicity. This is largely believde to be a result of ifosfamide-induced oxida...
The establish of the HPLC method to examine the plasma concentration of lamotrigine and oxcarbazepine
To establish the HPLC method to examine plasma concentration of lamotrigine and oxcarbazepine. This study set chlorzoxazone as the internal standard, chromatographic column was Column C18 (200×4.6mm, 5um) of DIKMA...