I. V. INFUSION OF MAGNESIUM SULPHATE DURING SPINAL ANAESTHESIA TO IMPROVE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LOWER EXTREMITY SURGERY.
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 25
Abstract
[b] BACKGROUND[/b]: In a randomized, double-blind, prospective study, we have evaluated the effect of i.v. infusion of magnesium sulphate during spinal anaesthesia, postoperative analgesia and postoperative analgesic requirements in patients undergoing lower extremity surgery. AIM: To evaluate the analgesic efficacy of I.V. infusion of magnesium sulphate during spinal anaesthesia on postoperative pain and analgesic consumption in patients undergoing lower extremity surgery. [b]METHODS AND MATERIAL[/b]: Sixty patients undergoing lower extremity surgery under spinal anaesthesia were included. After induction of spinal anaesthesia, the magnesium group (Group M) received intravenous infusion of magnesium sulphate where as in the saline group (Group S) the same volume of isotonic saline over the same period. After surgery, rescue analgesia in form of Inj. Tramadol 1 mg/kg iv was provided for the patients. The Postoperative pain scores, Rescue analgesic consumption, and incidences of shivering, postoperative nausea, and vomiting evaluated immediately after surgery, and at 30 min, 2, 4, 6, 12, 24 and 48 hr after surgery. Serum magnesium concentrations were checked before the induction of anaesthesia, immediately after surgery, and at 24 h after surgery. [b]STATISTICAL ANALYSIS[/b]: Results were expressed as mean and standard deviation. P value of <0.05 was considered statistically significant.[b] RESULTS[/b]: Postoperative pain scores were markedly lower in Group M at 4, 6, 12, 24, and 48 h after surgery. Cumulative postoperative rescue analgesia consumptions were markedly lower in Group M at 12, 24, and 48 h after surgery. Postoperative magnesium concentrations were higher in Group M immediately after surgery, but no side-effects associated with hypermagnesemia were observed. Haemodynamic variables and the incidences of shivering, nausea, and vomiting were similar in the two groups. [b]CONCLUSION[/b]: I.V. magnesium sulphate administration during spinal anaesthesia improves postoperative analgesia without any notable complications.
Authors and Affiliations
Vandana Tyagi, Akash Rajendra, Shashi Chaturvedi, Chaudhri R. S
Keywords
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- EP ID EP138183
- DOI 10.14260/jemds/883
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