In vitro antioxidant activity of methanolic extracts of various parts of Leptadenia pyrotechnica (Forssk.) Decne.
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
Leptadenia pyrotechnica is a desert plant and its unripe fruits are cooked as a vegetable. Besides, this plant is also used for treating various ailments by the dwellers, yet very little is known about its free radical scavenging activity. Methanolic extracts of aerial parts and roots of this plant were evaluated for their free radical scavenging activity through 2,2’ diphenyl-1-picrylhydrazyl (DPPH• ) scavenging, hydrogen peroxide scavenging and reducing power assays. Results revealed that there is strong free-radical scavenging activity lying in both parts comparable with synthetic antioxidant i.e. Butylated Hydroxy Anisole (BHA). The activity was found increased in a concentration-dependent manner. Root extracts showed significant DPPH• and hydrogen peroxide scavenging activity, whereas highest electron donating capacity was observed in aerial parts extracts (O.D. of 2.38) at a concentration of 100µg/mL. This research work will be helpful in the discovery of novel antioxidants from L. pyrotechnica that may replace synthetic antioxidants.
Authors and Affiliations
Mehmooda Munazir , Rahmatullah Qureshi , Mubashrah Munir
Keywords
Related Articles
- EP ID EP94919
- DOI -
- Views 100
- Downloads 0
Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate
The purpose of this study was to introduce the technology for the development of rate-controlled oral drug delivery system to overcome various physiological problems. Several approaches are being used for the purpo...
Curative effect of paclitaxel and cisplatin combined chemotherapy on cervical cancer and its relation with tissue micro vascular and lymphatic vessels density
This study was to discuss the curative effect of paclitaxel and cisplatin combined chemotherapy on cervical cancer and its relation with tissue micro vascular and lymphatic vessels density. The combined chemotherap...
Comparative bioavailability and pharmacokinetics of two oral formulations of flurbiprofen: A single-dose, randomized, open-label, two-period, crossover study in Pakistani subjects
Comparative bioavailability studies are conducted to establish the bioequivalence of generic formulation with that of branded reference formulation, providing confidence to clinicians to use these products intercha...
Unpredictable chronic mild stress induced behavioral deficits: A comparative study in male and female rats
Stress is an important precipitant factor for depression. Changes in various body systems that occur in depression are similar to those observed in response to stress. Chronic stress may alter behavioral, neurochem...
Chemical and biological evaluation of Ranunculus muricatus
Ranunculus muricatus is commonly known as spiny fruit buttercup and is used in the treatment of intermittent fevers, gout and asthma. Qualitative analysis of phytochemicals of Ranunculus muricatus indicated the pre...