INCIDENCE OF SUBCLINICAL NEUROPATHY IN NEWLY DIAGNOSED HIV POSITIVE PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 62
Abstract
BACKGROUND About 10-20% of HIV seropositive subjects present with neurological involvement and 50-70% have evidence of neurological involvement during the course of illness. Autopsy studies showed nervous system involvement in 80-90% of subjects. The commonest neurological complication is peripheral neuropathy, the Distal Symmetrical Sensory Neuropathy (DSP). METHODS We have conducted a prospective hospital based study to know the incidence of subclinical neuropathy in asymptomatic newly diagnosed HIV patients in the Department of Neurology, Gandhi Medical College, Secunderabad, Telangana state, a tertiary care teaching hospital. The study group was selected from the patient pool attending the regional Antiretroviral Therapy (ART) Clinic at Gandhi Hospital from 2012 to 2015. These patients do not have any symptoms suggestive of peripheral nerve involvement. However, clinical examination was abnormal in 40% of patients. These patients were not on ART drugs or do not have any chronic medical illness or hereditary or nutritional cause for neuropathy. Asymptomatic patients seropositive for HIV infection attending Gandhi Hospital from 2012 to 2015 were screened for evidence of neuropathy. Patients on antiretroviral treatment were excluded. Specific investigations were done to exclude other causes of neuropathy. RESULTS In our study of 200 HIV positive asymptomatic patients, the nerve conduction studies were normal in 62 patients. The other 128 patients have various abnormalities in nerve conduction studies in the form of asymptomatic sensory axonopathy, predominantly affecting the lower limbs (length dependent) in 54 patients, motor mononeuropathy and multiple mononeuropathies in 42 patients and sensorimotor demyelinating and axonal neuropathy in 42 patients. CONCLUSIONS The present study shows evidence of subclinical neuropathy in almost 69% of patients.
Authors and Affiliations
Veena , Dhairyawan
Keywords
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- EP ID EP139009
- DOI 10.14260/jemds/2016/991
- Views 107
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