Inhibition of nail infecting fungi of peoples of North Eastern U.P causing Tinea unguium through leaf essential oil of Ageratum houstonianum Mill
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 6
Abstract
A Clinical surveys was carried out in North Eastern Uttar Pradesh,India and 200 samples of nail infections were collected.Seven fungal species were isolated from infected nails viz.,Aspergillus flavus,A.fumigatus,A.niger,Candida albicans,Epidermophyton floccosum,Fusarium oxysporum,Trichophyton rubrum. They were microscopically examined that showed the dominance of Candida and Trichophyton on the basis of percent occurrence on infected nails of peoples of different age groups.These species were also present in both sterilized and unsterilized infected nails. From the leaves of 32 higher plants essential oils were isolated and tested against Candida and Trichophyton.,found dominantly associated with nail infections in peoples of North Eastern U.P districts. The essential oil of Ageratum houstonianum Mill(Asteraceae )was found strongest toxicant against the test fungi inhibiting mycelial growth at 500ppm. The minimum inhibitory concentration (MIC) of the oil was 400 ppm against Candida albicans and Trichophyton rubrum. However, it was found fungicidal at 500ppm against both test fungi respectively.The oil was effective on heavy doses of inoculums ( up to 10 discs of 5 mm each) at 400ppm.. The (MKT) of the oil was 30 sec against Candida albicans and 40 sec against T. rubrum.. The oils efficacy was thermo stable up to100°C and for 180 days of storage, the maximum taken into consideration. Moreover, on autoclaving there was no effect on fungitoxicity of oil.
Authors and Affiliations
Dr. Narendra Kumar
Keywords
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